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Hall, J. P. 
ORCID: https://orcid.org/0000-0003-3716-4378, Gurung, S. P., Henle, J., Poidl, P., Andersson, J., Lincoln, P., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995
(2017)
Guanine can direct binding specificity of Ru-dppz complexes to DNA through steric effects.
Chemistry: A European Journal, 23 (21).
pp. 4981-4985.
ISSN 0947-6539
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To link to this item DOI: 10.1002/chem.201605508
Abstract/Summary
X-ray crystal structures of three Λ-[Ru(L)2dppz]2+ complexes (L=phen, bpy) bound to d((5BrC)GGC/GCCG) show the compounds intercalated at a 5´-CG-3´ step. The compounds bind through canted intercalation, with the binding angle determined by the guanine-NH2 group, in contrast to symmetrical intercalation previously observed at 5´-TA-3´ sites. This result suggests that canted intercalation is preferred at 5´-CG-3´ sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5´-CG-3´ step could give rise to a longer luminescence lifetime than canted intercalation.
| Item Type: | Article |
|---|---|
| Refereed: | Yes |
| Divisions: | Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group |
| ID Code: | 68810 |
| Publisher: | Wiley |
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