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Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

Shortt, C., Hasselwander, O., Meynier, A., Nauta, A., Fernández, E. N., Putz, P., Rowland, I., Swann, J., Türk, J., Vermeiren, J. and Antoine, J.-M. (2018) Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients. European Journal of Nutrition, 57 (1). pp. 25-49. ISSN 1436-6215

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To link to this item DOI: 10.1007/s00394-017-1546-4


The systematic review demonstrates that the IM plays a major role in the breakdown and transformation of the dietary substrates examined. However, recent human data are limited with the exception of data from studies examining fibres and polyphenols. Results observed in relation with dietary substrates were not always consistent or coherent across studies and methodological limitations and differences in IM analyses made comparisons difficult. Moreover, non-digestible components likely to reach the colon are often not well defined or characterised in studies making comparisons between studies difficult if not impossible. Going forward, further rigorously controlled randomised human trials with well-defined dietary substrates and utilizing omic-based technologies to characterise and measure the IM and their functional activities will advance the field. Current evidence suggests that more detailed knowledge of the metabolic activities and interactions of the IM hold considerable promise in relation with host health.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:73504


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