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Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

Deiana, M., Serra, G. and Corona, G. (2018) Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds. Food & Function, 9 (8). pp. 4085-4099. ISSN 2042-650X

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To link to this item DOI: 10.1039/c8fo00354h


Dietary habits have been strongly linked to the maintenance of intestinal epithelium homeostasis, whose alteration may contribute to the pathogenesis of inflammatory diseases and cancer. Polyphenols are among those dietary components suggested to be beneficial for gut health. Within a balanced Mediterranean type diet, a good portion of ingested polyphenols comes from olives and extra virgin olive oil (EVOO). Most of them reach the intestine, where they may be directly absorbed or metabolized under absorption. Others undergo an extensive gastrointestinal biotransformation, producing various metabolites that retain the potential beneficial effect of the parent compounds, or exert a more efficient biological action themselves. Ingested EVOO polyphenols (EVOOP) and their metabolites will be particularly concentrated in the intestinal lumen, where they might exert a significant local action. In this review we summarize the few studies that investigated the effect of EVOOP at the intestinal level, focusing on the possible mechanism of action in relation to their interaction with the microbiota, and their ability to potentially modulate the oxidative status of the intestinal epithelial layer, inflammation and immune response.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:78823
Uncontrolled Keywords:Food Science, General Medicine
Publisher:Royal Society of Chemistry


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