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The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy

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Baptista, F. R., Devereux, S. J., Gurung, S. P., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Sazanovich, I. V., Towrie, M., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Kelly, J. M. and Quinn, S. J. (2020) The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy. Chemical Communications, 56 (67). pp. 9703-9706. ISSN 1359-7345

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To link to this item DOI: 10.1039/D0CC03702H

Abstract/Summary

Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the [Ru(phen)2(dppz)]2+ 1 “light-switch” complex to i-motif structures in solution. Detailed information is provided due to perturbation of the local base vibrations by a ‘Stark-like’ effect which is used to establish the contribution of thymine base loop interactions to the binding site of 1 in this increasingly relevant DNA structure.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
ID Code:91847
Publisher:The Royal Society of Chemistry
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