Article

Alharbi, Hajed O., Hardyman, Michelle A., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T. E., Glennon, Peter E., Fuller, Stephen J., Sugden, Peter H. and Clerk, Angela ORCID: https://orcid.org/0000-0002-5658-0708 (2022) Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice. Clinical Science, 136 (22). pp. 1661-1681. ISSN 0143-5221 doi: https://doi.org/10.1042/CS20220607

Clerk, Angela ORCID: https://orcid.org/0000-0002-5658-0708, Meijles, Daniel N., Hardyman, Michelle A., Fuller, Stephen J., Chothani, Sonia P., Cull, Joshua J., Cooper, Susanna T. E., Alharbi, Hajed O., Vanezis, Konstantinos, Felkin, Leanne E., Markou, Thomais, Leonard, Samuel J., Shaw, Spencer W., Rackham, Owen J. L., Cook, Stuart A., Glennon, Peter E., Sheppard, Mary N., Sembrat, John C., Rojas, Mauricio, McTiernan, Charles F., Barton, Paul J. and Sugden, Peter H. (2022) Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo. Biochemical Journal, 479 (3). pp. 401-424. ISSN 0264-6021 doi: https://doi.org/10.1042/BCJ20210615

Meijles, Daniel N., Fuller, Stephen J., Cull, Joshua J., Alharbi, Hajed O., Cooper, Susanna T. E., Sugden, Peter H. and Clerk, Angela ORCID: https://orcid.org/0000-0002-5658-0708 (2021) The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors. Biochemical Journal, 478 (11). pp. 2059-2079. ISSN 1470-8728 doi: https://doi.org/10.1042/BCJ20210144

Fuller, Stephen J., Edmunds, Nick S., McGuffin, Liam J ORCID: https://orcid.org/0000-0003-4501-4767, Hardyman, Michelle A., Cull, Joshua J., Alharbi, Hajed O., Meijles, Daniel N., Sugden, Peter H. and Clerk, Angela ORCID: https://orcid.org/0000-0002-5658-0708 (2021) MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins. Biochemical Journal, 478 (11). pp. 2121-2143. ISSN 0264-6021 doi: https://doi.org/10.1042/BCJ20210003

Fuller, Stephen J., Osborne, Sally A., Leonard, Sam J., Hardyman, Michelle A., Vaniotis, George, Allen, Bruce G., Sugden, Peter H. and Clerk, Angela (2015) Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts. Cardiovascular Research, 108 (1). pp. 87-98. ISSN 0008-6363 doi: https://doi.org/10.1093/cvr/cvv210

Amirak, Emre, Fuller, Stephen J., Sugden, Peter H. and Clerk, Angela (2013) p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists. Biochemical Journal, 450 (2). pp. 351-363. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20121371

Giraldo, Alejandro, Barrett, Oliver P. T., Tindall, Marcus J., Fuller, Stephen J., Amirak, Emre, Bhattacharya, Bonhi S., Sugden, Peter H. and Clerk, Angela (2012) Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target. Biochemical Journal, 444 (2). pp. 343-355. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20120125

Fuller, Stephen J, McGuffin, Liam J, Marshall, Andrew K, Giraldo, Alejandro, Pikkarainen, Sampsa, Clerk, Angela and Sugden, Peter (2012) A novel, non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3). Biochemical Journal, 442 (3). pp. 595-610. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20112000

Sugden, Peter H., Markou, Thomais, Fuller, Stephen John, Tham, El Li, Molkentin, Jeff D., Paterson, H. F. and Clerk, Angela (2011) Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cellular Signalling, 23 (2). pp. 468-477. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2010.10.024

Clerk, Angela, Cullingford, Timothy E., Fuller, Stephen J., Giraldo, Alejandro and Sugden, Peter H. (2009) Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2. Advances in Enzyme Regulation, 49 (1). pp. 30-42. ISSN 0065-2571 doi: https://doi.org/10.1016/j.advenzreg.2008.12.007

Sugden, Peter H., Fuller, Stephen J., Weiss, S. C. and Clerk, Angela (2008) Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. British Journal of Pharmacology, 153 (S1). S137-S153. ISSN 1476-5381 doi: https://doi.org/10.1038/sj.bjp.0707659

Markou, Thomais, Cullingford, Timothy E., Giraldo Ramirez, Alejandro, Weiss, Sophie C., Alsafi, Ali, Fuller, Stephen John, Clerk, Angela and Sugden, Peter H. (2008) Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition. Cellular Signalling, 20 (1). pp. 206-218. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2007.10.004

Fuller, Stephen John, Pikkarainen, Sampsa, Tham, El Li, Cullingford, Timothy E., Molkentin, Jeff D., Cornils, H, Hergovitch, A, Hemmings, B. A., Clerk, Angela and Sugden, Peter H. (2008) Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Cellular Signalling, 20 (8). pp. 1564-1577. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2008.04.013

Cullingford, Timothy E., Markou, T., Fuller, Stephen John, Giraldo, Alejandro, Pikkarainern, Sampsa, Zoumpoulidou, Georgia, Alsafi, A., Ekere, C., Kemp, Timothy J., Dennis, Jayne L., Game, Laurence, Sugden, Peter H. and Clerk, Angela (2008) Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes. Genome Biology, 9 (2). R32. ISSN 1474-760X doi: https://doi.org/10.1186/gb-2008-9-2-r32

Clerk, Angela, Cullingford, Timothy E., Fuller, Stephen J., Giraldo, Alejandro, Markou, Thomais, Pikkarainen, Sampsa and Sugden, Peter (2007) Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. Journal of cellular physiology, 212 (2). pp. 311-322. ISSN 0021-9541 doi: https://doi.org/10.1002/jcp.21094