2021

Meijles, D. N., Cull, J. J., Cooper, S. T. E., Markou, T., Hardyman, M. A., Fuller, S. J., Alharbi, H. O., Haines, Z. H. R., Alcantara Alonso, V. ORCID: https://orcid.org/0000-0002-9782-2398, Glennon, P. E., Sheppard, M. N., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2021) The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension. Clinical Science, 135 (14). pp. 1631-1647. ISSN 0143-5221 doi: https://doi.org/10.1042/CS20210192

Meijles, D. N., Fuller, S. J., Cull, J. J., Alharbi, H. O., Cooper, S. T. E., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2021) The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors. Biochemical Journal, 478 (11). pp. 2059-2079. ISSN 1470-8728 doi: https://doi.org/10.1042/BCJ20210144

2020

St George's Hospital Medical School (2020) Treatment of fibrosis With RAF inhibitors. WO 2020/161477. doi: WO 2020/161477

2019

Novelli, E. M., Little-Ihrig, L., Knupp, H. E., Rogers, N. M., Yao, M., Baust, J. J., Meijles, D., St. Croix, C. M., Ross, M. A., Pagano, P. J., DeVallance, E. R., Miles, G., Potoka, K. P., Isenberg, J. S. and Gladwin, M. T. (2019) Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice. American Journal of Physiology-Lung Cellular and Molecular Physiology, 316 (6). L1150-L1164. ISSN 1522-1504 doi: https://doi.org/10.1152/ajplung.00302.2018

Meijles, D. N., Zoumpoulidou, G., Markou, T., Rostron, K. A., Patel, R., Lay, K., Handa, B. S., Wong, B., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2019) The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death. Journal of molecular and cellular cardiology, 129. pp. 118-129. ISSN 1095-8584 doi: https://doi.org/10.1016/j.yjmcc.2019.02.006

2016

Meijles, D. N., Fan, L. M., Ghazaly, M. M., Howlin, B., Krönke, M., Brooks, G. and Li, J.-m. ORCID: https://orcid.org/0000-0002-3294-3818 (2016) p22phox C242T SNP inhibits inflammatory oxidative damage to endothelial cells and vessels. Circulation, 133 (24). pp. 2391-2403. ISSN 1524-4539 doi: https://doi.org/10.1161/CIRCULATIONAHA.116.021993

Sahoo, S., Meijles, D. N., Al Ghouleh, I., Tandon, M., Cifuentes-Pagano, E., Sembrat, J., Rojas, M., Goncharova, E. and Pagano, P. J. (2016) MEF2C-MYOCD and leiomodin1 suppression by miRNA-214 promotes smooth muscle cell phenotype switching in pulmonary arterial hypertension. PLoS ONE, 11 (5). e0153780. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0153780

2014

Meijles, D. N., Fan, L. M., Howlin, B. J. and Li, J.-m. ORCID: https://orcid.org/0000-0002-3294-3818 (2014) Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production. The Journal of Biological Chemistry, 289 (33). pp. 22759-22770. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M114.561159