Accessibility navigation


Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

Olano-Martin, E., Abraham, E. C., Gill-Garrison, R., Valdes, A. M., Grimaldi, K., Tang, F., Jackson, K. G., Williams, C. M. and Minihane, A. M. (2008) Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. Journal of Lipid Research, 49 (5). pp. 945-953. ISSN 0022-2275

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1194/jlr.M700112-JLR200

Abstract/Summary

Although apolipoprotein AN (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender X genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males. Lower HDL-cholesterol was associated with the rare TC genotype (P = 0.047). Significant linkage disequilibrium was found between the apoA-V -1131 T>C and the apoC-III 3238 C>G variants, with univariate analysis indicating an impact of this apoC-III single nucleotide polymorphism (SNP) on TG AUC (P = 0.015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13113
Uncontrolled Keywords:polymorphism, apolipoprotein A-V, apoA1/C3/A4/A5 gene locus, postprandial lipemia, FAMILIAL COMBINED HYPERLIPIDEMIA, CORONARY-ARTERY-DISEASE, APOLIPOPROTEIN A5 GENE, DENSITY-LIPOPROTEIN CHOLESTEROL, PLASMA, TRIGLYCERIDE, HEART-DISEASE, CLUSTER, LIPASE, RISK, POLYMORPHISM

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation