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Methodology for studying postprandial lipid metabolism

Lairon, D., Lopez-Miranda, J. and Williams, C. (2007) Methodology for studying postprandial lipid metabolism. European Journal of Clinical Nutrition, 61 (10). pp. 1145-1161. ISSN 0954-3007

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To link to this article DOI: 10.1038/sj.ejcn.1602749

Abstract/Summary

Background: Postprandial lipid metabolism in humans has deserved much attention during the last two decades. Although fasting lipid and lipoprotein parameters reflect body homeostasis to some extent, the transient lipid and lipoprotein accumulation that occurs in the circulation after a fat-containing meal highlights the individual capacity to handle an acute fat input. An exacerbated postprandial accumulation of triglyceride-rich lipoproteins in the circulation has been associated with an increased cardiovascular risk. Methods: The important number of studies published in this field raises the question of the methodology used for such postprandial studies, as reviewed. Results: Based on our experiences, the present review reports and discuss the numerous methodological issues involved to serve as a basis for further works. These aspects include aims of the postprandial tests, size and nutrient composition of the test meals and background diets, pre-test conditions, characteristics of subjects involved, timing of sampling, suitable markers of postprandial lipid metabolism and calculations. Conclusion: In conclusion, we stress the need for standardization of postprandial tests.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13230
Uncontrolled Keywords:nutrition, human, meals, gene polymorphisms, cardiovascular disease, TRIGLYCERIDE-RICH LIPOPROTEINS, DIETARY FATTY-ACIDS, DEPENDENT, DIABETES-MELLITUS, FISH-OIL SUPPLEMENTATION, CORONARY-ARTERY DISEASE, HEALTHY-YOUNG MEN, MIDDLE-AGED MEN, APOLIPOPROTEIN B-48, OLIVE OIL, NORMOLIPIDEMIC ADULTS

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