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Distribution of [H-3]trans-resveratrol in rat tissues following oral administration

El Mohsen, M.A., Bayele, H., Kuhnle, G., Gibson, G., Debnam, E., Srai, S.K., Rice-Evans, C. and Spencer, J.P.E. (2006) Distribution of [H-3]trans-resveratrol in rat tissues following oral administration. British Journal of Nutrition, 96 (1). pp. 62-70. ISSN 0007-1145

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To link to this article DOI: 10.1079/bjn20061810

Abstract/Summary

Resveratrol has been widely investigated for its potential health properties, although little is known about its metabolism in vivo. Here we investigated the distribution of metabolic products of [H-3]trans-resveratrol, following gastric administration. At 2 h, plasma concentrations reached 1 center dot 7 % of the administered dose, whilst liver and kidney concentrations achieved 1 center dot 0 and 0 center dot 6 %, respectively. Concentrations detected at 18 h were lower, being only 0 center dot 5 % in plasma and a total of 0 center dot 35 % in tissues. Furthermore, whilst kidney and liver concentrations fell to 10 and 25 %, respectively, of concentrations at 2 h, the brain retained 43 % of that measured at 2 h. Resveratrol-glucuronide was identified as the major metabolite, reaching 7 mu m in plasma at 2 h. However, at 18 h the main form identified in liver, heart, lung and brain was native resveratrol aglycone, indicating that it is the main form retained in the tissues. No phenolic degradation products were detected in urine or tissues, indicating that, unlike flavonoids, resveratrol does not appear to serve as a substrate for colonic microflora. The present study provides additional information about the nature of resveratrol metabolites and which forms might be responsible for its in vivo biological effects.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13452
Uncontrolled Keywords:resveratrol, metabolism, polyphenol, radioactive, distribution, TRANS-RESVERATROL, METABOLISM, HUMANS, POLYPHENOLS, ABSORPTION, WINE, BIOAVAILABILITY, DERIVATIVES, ACID

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