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The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation

Corona, G., Tzounis, X., Dessi, M.A., Deiana, M., Debnam, E.S., Visioli, F. and Spencer, J.P.E. (2006) The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Free Radical Research, 40 (6). pp. 647-658. ISSN 1071-5762

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To link to this article DOI: 10.1080/10715760500373000

Abstract/Summary

We have conducted a detailed investigation into the absorption, metabolism and microflora-dependent transformation of hydroxytyrosol ( HT), tyrosol (TYR) and their conjugated forms, such as oleuropein (OL). Conjugated forms underwent rapid hydrolysis under gastric conditions, resulting in significant increases in the amount of free HT and TYR entering the small intestine. Both HT and TYR transferred across human Caco-2 cell monolayers and rat segments of jejunum and ileum and were subject to classic phase I/II biotransformation. The major metabolites identified were an O-methylated derivative of HT, glucuronides of HT and TYR and a novel glutathionylated conjugate of HT. In contrast, there was no absorption of OL in either model. However, OL was rapidly degraded by the colonic microflora resulting in the formation of HT. Our study provides additional information regarding the breakdown of complex olive oil polyphenols in the GI tract, in particular the stomach and the large intestine.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13484
Uncontrolled Keywords:olive oil, hydroxytyrosol, tyrosol, absorption, metabolism, colonic, microflora, EPITHELIAL CACO-2 CELLS, LOW-DENSITY-LIPOPROTEIN, IN-VIVO METABOLITES, UDP-GLUCURONOSYLTRANSFERASES, DIETARY POLYPHENOLS, URINARY-EXCRETION, CELLULAR UPTAKE, SMALL-INTESTINE, HYDROXYTYROSOL, HUMANS

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