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Diet, ageing and genetic factors in the pathogenesis of diverticular disease

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Commane, D. M., Arasaradnam , R. P., Mills, S., Mathers, J. C. and Bradburn, M. (2009) Diet, ageing and genetic factors in the pathogenesis of diverticular disease. World Journal of Gastroenterology, 15 (20). pp. 2479-2488. ISSN 1007-9327

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To link to this article DOI: 10.3748/wjg.15.2479

Abstract/Summary

Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
No Reading authors. Back catalogue items
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:16068
Publisher:Baishideng Publishing Group

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