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Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome

Gulseth, H. L., Gjelstad , I. M.F., Tierney, A. C., Lovegrove, J. A., Defoort , C., Blaak, E. E., Lopez-Miranda, J., Kiec-Wilk , B., Ris, U., Roche, H. M., Drevon, C. A. and Birkeland, K. I. (2010) Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care, 33 (4). pp. 923-925. ISSN 1935-5548 (Erratum in: Diabetes Care. 2010 Dec; 33(12) p2725. Ris, Ulférus [corrected to Risérus, Ulf])

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To link to this article DOI: 10.2337/dc09-1692

Abstract/Summary

OBJECTIVE To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry. RESULTS The 25(OH)D3 concentration was 57.1 ± 26.0 nmol/l (mean ± SD), and only 20% of the subjects had 25(OH)D3 levels ≥75 nmol/l. In multiple linear analyses, 25(OH)D3 concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates. CONCLUSIONS In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D3 did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:16374
Additional Information:erratum listed at http://care.diabetesjournals.org/content/33/4/923
Publisher:American Diabetes Association

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