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Trans fatty acids insulin resistance and diabetes

Thompson, A. K., Minihane, A.-M. and Williams, C. M. (2010) Trans fatty acids insulin resistance and diabetes. European Journal of Clinical Nutrition, 65. pp. 553-564. ISSN 1476-5640

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To link to this article DOI: 10.1038/ejcn.2010.240

Abstract/Summary

The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade. This review evaluates the evidence, and concludes that there is limited evidence for a weak association at high TFA intakes, but very little convincing evidence that habitual exposure as part of a standard western diet has a significant contribution to risk of diabetes or insulin resistance. The possibility of increased risk for individuals with particular genotypes (such as the FABP2 Thr54 allele) is of interest, but further work would be required to provide sufficient evidence of any association.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:19138
Uncontrolled Keywords:diabetes; insulin; insulin resistance; insulin sensitivity trans fatty acids; trans FA
Publisher:Nature Publishing Group

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