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Ageing impairs the T cell response to dendritic cells

You, J., Dong, H., Mann, E., Knight, S. and Yaqoob, P. (2013) Ageing impairs the T cell response to dendritic cells. Immunobiology, 218 (8). pp. 1077-1084. ISSN 0171-2985

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To link to this item DOI: 10.1016/j.imbio.2013.02.002

Abstract/Summary

Dendritic cells (DCs) are critical in priming adaptive T-cell responses, but the effects of ageing on interactions between DCs and T cells are unclear. This study investigated the influence of ageing on the maturation of and cytokine production by human blood-enriched DCs, and the impact on T cell responses in an allogeneic mixed leucocyte reaction (MLR). DCs from old subjects (65-75y) produced significantly less TNF-α and IFN-γ than young subjects (20-30y) in response to lipopolysaccharide (LPS), but expression of maturation markers and co-stimulatory molecules was preserved. In the MLR, DCs from older subjects induced significantly restricted proliferation of young T cells, activation of CD8+ T cells and expression of IL-12 and IFN-γ in T cells compared with young DCs. T cells from older subjects responded more weakly to DC stimulation compared with young T cells, regardless of whether the DCs were derived from young or older subjects. In conclusion, the capacity of DCs to induce T cell activation is significantly impaired by ageing.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:32827
Uncontrolled Keywords:Ageing; Cytokine; Dendritic cells; Mixed leucocyte reaction; T cell activation
Publisher:Elsevier

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