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Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency

Vimaleswaran, K. S., Cavadino, A. and Hyppönen, E. (2012) Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency. Allergy, 67 (8). pp. 1033-1040. ISSN 1398-9995

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To link to this item DOI: 10.1111/j.1398-9995.2012.02856.x

Abstract/Summary

Our study on white European adults was consistent with a previous study on children from largely non-white ethnic groups, suggesting that IL4 and MS4A2 genotypes modify the association between VDD and allergy risk. The risk allele in IL4 is present in nearly 90% of white Europeans, while less than a quarter are carriers in some other populations, highlighting the need to consider possible ethnic differences in allergy-related responsiveness to VDD.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:34645
Uncontrolled Keywords:1958 British birth cohort;25-hydroxyvitamin D;allergy;gene × environment interaction;total IgE
Publisher:Wiley

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