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Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis

Vaiyapuri, S., Flora, G. D. and Gibbins, J. M. (2015) Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochemical Society Transactions, 43 (3). pp. 489-494. ISSN 1470-8752

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To link to this item DOI: 10.1042/BST20150055

Abstract/Summary

Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and ischemic stroke. Although platelets circulate in isolation, upon activation they accumulate or aggregate together to form a thrombus, where they function in a coordinated manner to prevent loss of blood and control wound repair. Recent reports indicate that the stability and functions of a thrombus are maintained through sustained, contact dependent signalling between platelets. Given the role of gap junctions in the coordination of tissue responses, it was hypothesized that gap junctions may be present within a thrombus and mediate intercellular communication between platelets. Therefore studies were performed to explore the presence and functions of connexins in platelets. In this brief review, the roles of hemichannels and gap junctions in the control of thrombosis and haemostasis and the future directions for this research will be discussed.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:40338
Uncontrolled Keywords:Platelets; Gap junctions; hemichannels; thrombosis; haemostasis
Publisher:Portland Press

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