Accessibility navigation


Female-specific intergenerational transmission patterns of the human corticolimbic circuitry

Downloads

Downloads per month over past year

Yamagata, B., Murayama, K., Black, J., M., Hancock, R., Mimura, M., Yang, T. T., Reiss, A., L. and Hoeft, F. (2016) Female-specific intergenerational transmission patterns of the human corticolimbic circuitry. The Journal of Neuroscience, 36 (4). pp. 1254-1260. ISSN 1529-2401

[img] Text - Accepted Version
· Restricted to Repository staff only until 28 July 2016.

710Kb

To link to this article DOI: 10.1523/JNEUROSCI.4974-14.2016

Abstract/Summary

Parents have large genetic and environmental influences on offspring’s cognition, behavior, and brain. These intergenerational effects are observed in mood disorders, with particularly robust association in depression between mothers and daughters. No studies have thus far examined the neural bases of these intergenerational effects in humans. Corticolimbic circuitry is known to be highly relevant in a wide range of processes including mood regulation and depression. These findings suggest that corticolimbic circuitry may also show matrilineal transmission patterns. We therefore examined human parent-offspring association in this neurocircuitry, and investigated the degree of association in gray matter volume between parent and offspring. We used voxel-wise correlation analysis in a total of 35 healthy families, consisting of parents and their biological offspring. We found positive associations of regional grey matter volume in the corticolimbic circuit including the amygdala, hippocampus, anterior cingulate cortex, and ventromedial prefrontal cortex between biological mothers and daughters. This association was significantly greater than mother-son, father-daughter, and father-son associations. The current study suggests that the corticolimbic circuitry, which has been implicated in mood regulation, shows a matrilineal specific transmission patterns. Our preliminary findings are consistent with what has been found behaviorally in depression, and may have clinical implications for disorders known to have dysfunction in mood regulation such as depression. Studies such as ours will likely bridge animal work examining gene expression in the brains and clinical symptom-based observations, and provide promising ways to investigate intergenerational transmission patterns in the human brain.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Development
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Social
ID Code:49005
Publisher:The Society for Neuroscience

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation