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Dietary fatty acids and chylomicron synthesis and secretion

Williams, C. M., Bateman, P. A., Jackson, K. G. and Yaqoob, P. (2004) Dietary fatty acids and chylomicron synthesis and secretion. Biochemical Society Transactions, 32 (1). pp. 55-58. ISSN 1470-8752

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Official URL: http://www.biochemsoctrans.org/bst/032/0055/bst032...

Abstract/Summary

There is currently considerable interest in potential atherogenic and thrombogenic consequences of elevated concentrations of triacylglycerols, especially in the post-prandial state. Despite this, there is limited information on the effects of dietary fatty acids on the synthesis, secretion and metabolism of chylomicrons, the large triacylglycerol-rich lipoproteins synthesized in the enterocyte following the digestion and absorption of dietary fat. This brief review considers current approaches to the investigation of chylomicron synthesis and summarizes some of the human, cell and animal studies that have investigated effects of different fatty acids on these pathways. Potential sites for modulatory effects of dietary fatty acids on the molecular events of chylomicron synthesis are proposed in the light of the recent model that has been developed from cell and animal studies and observations based on abnormalities in chylomicron formation in human inherited autosomal recessive diseases.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:5966
Uncontrolled Keywords:Caco-2 cell chylomicron fatty acid human rabbit enterocyte
Additional Information:Paper presented at the 44th International Conference on the Bioscience of Lipids, Keble College, Oxford, 7–11 September 2003
Publisher:Portland Press

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