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A high-fat diet temporarily accelerates gastrointestinal transit and reduces satiety in men

Clegg, M. E. and Shafat, A. (2011) A high-fat diet temporarily accelerates gastrointestinal transit and reduces satiety in men. International Journal of Food Sciences and Nutrition, 62 (8). pp. 857-64. ISSN 1465-3478

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To link to this item DOI: 10.3109/09637486.2011.587793

Abstract/Summary

High-fat (HF) diets of 2 weeks have been shown to accelerate gastrointestinal (GI) transit and decrease satiety. However, the effects of HF diets on GI transit over longer periods than 2 weeks are unknown. We hypothesize that over 4 weeks, GI transit of a HF test meal will accelerate. The study was a repeated measures design with 10 male volunteers completing a 1-week HF diet intervention and 7 completing a 4-week HF diet intervention with testing once a week on the same day throughout the 4 weeks. Gastric emptying (GE) was measured using the (13)C-octanoic acid breath test and mouth-to-caecum transit time (MCTT) using the inulin H(2) breath test. Satiety was analysed using visual analogue scales and an ad libitum buffet meal. Body mass increased by 1.3 kg over the 4 weeks (p = 0.036). GE latency time decreased from 45 +/- 8 to 41 +/- 10 min (p = 0.047) over 1 week but there were no changes in any GE parameters over the 4 weeks. MCTT was accelerated over 1 week (p = 0.036) from 308 +/- 43 to 248 +/- 83 min. However, over the 4-week period, there was no change. Volunteers became more hungry and desire to eat became greater after 1 week (p = 0.01). Changes in satiety were also evident over the 4 weeks. Satiety was reduced in the primary weeks and then returned to baseline towards the end of the intervention. GI adaptation to a HF diet occurred over a 1-week period and returned to pre-diet levels at the end of 4 weeks.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:80406
Uncontrolled Keywords:Adolescent Adult Appetite/*drug effects Body Weight/*drug effects Breath Tests Diet, High-Fat/*adverse effects Dietary Fats/*adverse effects Gastric Emptying/*drug effects Gastrointestinal Transit/*drug effects Humans Hydrogen/metabolism Inulin/metabolism Male Satiety Response/*drug effects Young Adult
Publisher:Informa Healthcare

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