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Items where Author is "Cottrell, Dr Graeme"

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Stephens, G. J. and Cottrell, G. S. (2019) CACHD1: a new activity-modifying protein for voltage-gated calcium channels. Channels, 13 (1). pp. 120-123. ISSN 1933-6969 doi: https://doi.org/10.1080/19336950.2019.1600968

Widera, D., Martinez-Aguilar, R. and Cottrell, G. (2019) Toll-like 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation? Neural Regeneration Research, 14 (7). pp. 1196-1201. ISSN 1876-7958 doi: https://doi.org/10.4103/1673-5374.251290

Cottrell, G. S., Soubrane, C. H., Hounshell, J. A., Lin, H., Owenson, V., Rigby, M., Cox, P. J., Barker, B. S., Ottolini, M., Ince, S., Bauer, C. C., Perez-Reyes, E., Patel, M. K., Stevens, E. B. and Stephens, G. J. (2018) CACHD1 is an α2δ-like protein that modulates CaV3 voltage-gated calcium channel activity. The Journal of Neuroscience, 38 (4). pp. 9186-9201. ISSN 1529-2401 doi: https://doi.org/10.1523/JNEUROSCI.3572-15.2018

Leksmono, C., Manzoni, C., Tomkins, J., Lucchesi, W., Cottrell, G. and Lewis, P. A. (2018) Measuring lactase enzymatic activity in the teaching lab. Journal of Visualized Experiments (138). e54377. ISSN 1940-087X

Roosterman, D., Meyerhof, W. and Cottrell, G. S. (2018) Proton transport chains in glucose metabolism: mind the proton. Frontiers in Neuroscience, 12. 404. ISSN 1662-453X doi: https://doi.org/10.3389/fnins.2018.00404

Limbu, R., Cottrell, G. S. and McNeish, A. J. (2018) Characterisation of the vasodilation effects of DHA and EPA, n-3 PUFAs (fish oils), in rat aorta and mesenteric resistance arteries. PLoS ONE, 13 (2). e0192484. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0192484

Krüger, C. L., Zeuner, M.-T., Cottrell, G. S., Widera, D. and Heilemann, M. (2017) Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization. Science Signaling, 10 (503). eaan1308. ISSN 1937-9145 doi: https://doi.org/10.1126/scisignal.aan1308

Zeuner, M.-T., Vallance, T., Vaiyapuri, S., Cottrell, G. S. and Widera, D. (2017) Development and characterisation of a novel NF-κB reporter cell line for investigation of neuroinflammation. Mediators of inflammation, 2017. 6209865. ISSN 0962-9351 doi: https://doi.org/10.1155/2017/6209865

Roux, B. T., Bauer, C. C., McNeish, A. J., Ward, S. G. and Cottrell, G. S. (2017) The role of ubiquitination and hepatocyte growth factor-regulated tyrosine kinase substrate in the degradation of the adrenomedullin type I receptor. Scientific Reports, 7 (1). p. 12389. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-017-12585-z

Zeuner, M.-T., Krueger, C. L., Volk, K., Bieback, K., Cottrell, G. S., Heilemann, M. and Widera, D. (2016) Biased signalling is an essential feature of TLR4 in glioma cells. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (12). pp. 3084-3095. ISSN 0167-4889 doi: https://doi.org/10.1016/j.bbamcr.2016.09.016

Roux, B. T. and Cottrell, G. S. (2014) G protein-coupled receptors: what a difference a 'partner' makes. International Journal of Molecular Sciences, 15 (1). pp. 1112-1142. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms15011112

Jensen, D., Godfrey, C. B., Niklas, C., Canals, M., Kocan, M., Poole, D. P., Murphy, J. E., Alemi, F., Cottrell, G. S., Korbmacher, C., Lambert, N. A., Bunnett, N. W. and Corvera, C. U. (2013) The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. The Journal of biological chemistry, 288 (32). pp. 22942-22960. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M113.455774

Cottrell, G. S. (2013) Roles of proteolysis in regulation of G protein-coupled receptor function. British Journal of Pharmacology, 168 (3). pp. 576-590. ISSN 1476-5381 doi: https://doi.org/10.1111/j.1476-5381.2012.02234.x

Alemi, F., Kwon, E., Poole, D. P., Lieu, T., Lyo, V., Cattaruzza, F., Cevikbas, F., Steinhoff, M., Nassini, R., Materazzi, S., Guerrero-Alba, R., Valdez-Morales, E., Cottrell, G., Schoonjans, K., Geppetti, P., Vanner, S. J., Bunnett, N. W. and Corvera, C. U. (2013) The TGR5 receptor mediates bile acid-induced itch and analgesia. The Journal of Clinical Investigation, 123 (4). pp. 1513-1530. ISSN 0021-9738 doi: https://doi.org/10.1172/JCI64551

McNeish, A., Roux, B. T., Aylett, S.-B., Van Den Brink, A. M. and Cottrell, G. S. (2012) Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. British Journal of Pharmacology, 167 (8). pp. 1679-1690. ISSN 1476-5381 doi: https://doi.org/10.1111/j.1476-5381.2012.02129.x

McNeish, A. J., Altayo-Jimenez, F., Cottrell, G. S. and Garland, C. J. (2012) Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (KCa2.3) in cerebral arteries. PLoS ONE, 7 (10). e46735. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0046735

Cottrell, G. S., Alemi, F., Kirkland, J. G., Grady, E. F., Corvera, C. U. and Bhargava, A. (2012) Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract. Peptides, 35 (2). pp. 202-211. ISSN 0196-9781 doi: https://doi.org/10.1016/j.peptides.2012.03.020

Murphy, J. E.,, Roosterman, D., Cottrell, G. S., Padilla, B. E., Feld, M., Brand, E., Cedron, W. J., Bunnett, N. W. and Steinhoff, M. (2011) Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. American Journal of Physiology. Cell Physiology, 301 (4). C780-C791. ISSN 1522-1563 doi: https://doi.org/10.1152/ajpcell.00096.2011

Pelayo, J.-C., Poole, D. P., Steinhoff, M., Cottrell, G. S. and Bunnett, N. W. (2011) Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. Journal of Physiology, 589 (21). pp. 5213-5230. ISSN 1469-7793 doi: https://doi.org/10.1113/jphysiol.2011.214452

Bunnett, N. W. and Cottrell, G. S. (2010) Trafficking and signaling of G protein-coupled receptors in the nervous system: implications for disease and therapy. CNS & Neurological Disorders - Drug Targets, 9 (5). pp. 539-556. ISSN 1996-3181 doi: https://doi.org/10.2174/187152710793361621

Poole, D.P., Godfrey, C., Cattaruzza, F., Cottrell, G.S., Kirkland, J.G., Pelayo, J.C., Bunnett, N.W. and Corvera, C.U. (2010) Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterology and Motility, 22 (7). 814-e228. ISSN 1365-2982 doi: https://doi.org/10.1111/j.1365-2982.2010.01487.x

Eilers, H., Cattaruzza, F., Nassini, R., Materazzi, S., Andre, E., Chu, C., Cottrell, G. S., Schumacher, M., Geppetti, P. and Bunnett, N. W. (2010) Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology, 112 (6). pp. 1452-1463. ISSN 1528-1175 doi: https://doi.org/10.1097/ALN.0b013e3181d94e00

Amadesi, S., Grant, A. D., Cottrell, G., Vaksmam, N., Poole, D. P., Rozengurt, E. and Bunnett, N. W. (2009) Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2. Journal of Comparative Neurology, 516 (2). pp. 141-156. ISSN 1096-9861 doi: https://doi.org/10.1002/cne.22104

Cottrell, G., Padilla, B. E., Amadesi, S., Poole, D. P., Murphy, J. E., Hardt, M., Roosterman, D., Steinhoff, M. and Bunnett, N. W. (2009) Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. Journal of Biological Chemistry, 284 (33). pp. 22411-22425. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M109.026674

Cattaruzza, F., Cottrell, G.S., Vaksman, N. and Bunnett, N.W. (2009) Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. British Journal of Pharmacology, 156 (5). pp. 730-739. ISSN 1476-5381 doi: https://doi.org/10.1111/j.1476-5381.2008.00039.x

Hasdemir, B., Murphy, J. E., Cottrell, G. S. and Bunnett, N. W. (2009) Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. Journal of Biological Chemistry, 284 (41). pp. 28453-28466. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M109.025692

Murphy, J. E., Padilla, B. E., Hasdemir, B., Cottrell, G. S. and Bunnett, N. W. (2009) Endosomes: a legitimate platform for the signaling train. Proceedings of the National Academy of Sciences of the United States of America, 106 (42). pp. 17615-17622. ISSN 1091-6490 doi: https://doi.org/10.1073/pnas.0906541106

Roosterman, D., Kempkes, C., Cottrell, G. S., Padilla, B. E., Bunnett, N. W., Turck, C. W. and Steinhoff, M. (2008) Endothelin-converting enzyme-1 degrades internalized somatostatin-14. Endocrinology, 149 (5). pp. 2200-2207. ISSN 1945-7170 doi: https://doi.org/10.1210/en.2007-1628

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G. S., Gatti, R., Basbaum, A. I., Bunnett, N. W., Julius, D. and Geppetti, P. (2007) 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proceedings of the National Academy of Sciences of the United States of America, 104 (33). pp. 13519-13524. ISSN 0027-8424 doi: https://doi.org/10.1073/pnas.0705923104

Roosterman, D., Kreuzer, O. J., Brune, N., Cottrell, G. S., Bunnett, N. W., Meyerhof, W. and Steinhoff, M. (2007) Agonist-induced endocytosis of rat somatostatin receptor 1. Endocrinology, 148 (3). pp. 1050-1058. ISSN 1945-7170 doi: https://doi.org/10.1210/en.2006-1600

Kirkland, J. G., Cottrell, G. S., Bunnett, N. W. and Corvera, C. U. (2007) Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. American Journal of Physiology Gastrointestinal and Liver Physiology, 293 (1). G335-G346. ISSN 0193-1857 doi: https://doi.org/10.1152/ajpgi.00425.2006

Roosterman, D., Cottrell, G. S., Padilla, B. E., Muller, L., Eckman, C. B., Bunnett, N. W. and Steinhoff, M. (2007) Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proceedings of the National Academy of Sciences of the United States of America, 104 (28). pp. 11838-11843. ISSN 0027-8424 doi: https://doi.org/10.1073/pnas.0701910104

Padilla, B. E., Cottrell, G. S., Roosterman, D., Pikios, S., Muller, L., Steinhoff, M. and Bunnett, N. W. (2007) Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Journal of Cell Biology, 179 (5). pp. 981-997. ISSN 0021-9525 doi: https://doi.org/10.1083/jcb.200704053

Hasdemir, B., Bunnett, N. W. and Cottrell, G. S. (2007) Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor. The Journal of Biological Chemistry, 282 (40). pp. 29646-57. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M702974200

Cottrell, G. S., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Grady, E. F. and Bunnett, N. W. (2007) Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. The Journal of Biological Chemistry, 282 (16). pp. 12260-12271. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M606338200

Grant, A. D., Cottrell, G. S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G. W., Bautista-Cruz, F., Lopez, C. B., Joseph, E. K., Levine, J. D., Liedtke, W., Vanner, S., Vergnolle, N., Geppetti, P. and Bunnett, N. W. (2007) Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. Journal of Physiology, 578 (3). pp. 715-733. ISSN 0022-3751 doi: https://doi.org/10.1113/jphysiol.2006.121111

Cottrell, G. S., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J. A., Murphy, B. R., Caughey, G. H., Wolters, P. J., Coughlin, S. R., Peterson, A., Knecht, W., Pothoulakis, C., Bunnett, N. W. and Grady, E. F. (2007) Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology, 132 (7). pp. 2422-2437. ISSN 0016-5085 doi: https://doi.org/10.1053/j.gastro.2007.03.101

Cenac, N. ., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G. S., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., Sharkey, K. A., Ferraz, J. G., Shaffer, E. and Vergnolle, N. (2007) Role for protease activity in visceral pain in irritable bowel syndrome. The Journal of Clinical Investigation, 117 (3). pp. 636-647. ISSN 0021-9738 doi: https://doi.org/10.1172/JCI29255

Gazzieri, D., Trevisani, M., Springer, J., Harrison, S., Cottrell, G. S., Andre, E., Nicoletti, P., Massi, D., Zecchi, S., Nosi, D., Santucci, M., Gerard, N. P., Lucattelli, M., Lungarella, G., Fischer, A., Grady, E. F., Bunnett, N. W. and Geppetti, P. (2007) Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury. Free Radical Biology and Medicine, 43 (4). pp. 581-589. ISSN 0891-5849 doi: https://doi.org/10.1016/j.freeradbiomed.2007.05.018

Knecht, W., Cottrell, G. S., Amadesi, S., Mohlin, J., Skaregarde, A., Gedda, K., Peterson, A., Chapman, K., Hollenberg, M. D., Vergnolle, N. and Bunnett, N. W. (2007) Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. The Journal of Biological Chemistry, 282 (36). pp. 26089-26100. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M703840200

Amadesi, S., Cottrell, G. S., Divino, L., Chapman, K., Grady, E. F., Bautista, F., Karanjia, R., Barajas-Lopez, C., Vanner, S., Vergnolle, N. and Bunnett, N. W. (2006) Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. Journal of Physiology, 575 (2). pp. 555-571. ISSN 0022-3751 doi: https://doi.org/10.1113/jphysiol.2006.111534

Oikonomopoulou, K., Hansen, K. K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S. I., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G. S., Bunnett, N. W., Diamandis, E. P. and Hollenberg, M. D. (2006) Proteinase-activated receptors, targets for kallikrein signaling. The Journal of Biological Chemistry, 281 (43). pp. 32095-32112. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M513138200

Cottrell, G. S., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Gehringer, D., Grady, E. F. and Bunnett, N. W. (2006) Ubiquitin-dependent down-regulation of the neurokinin-1 receptor. The Journal of Biological Chemistry, 281 (38). pp. 27773-27783. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M603369200

Cottrell, G. S., Roosterman, D., Marvizon, J.-C., Song, B., Wick, E., Pikios, S., Wong, H., Berthelier, C., Tang, Y., Sternini, C., Bunnett, N. W. and Grady, E. F. (2005) Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. Journal of Comparative Neurology, 490 (3). pp. 239-255. ISSN 1096-9861 doi: https://doi.org/10.1002/cne.20669

Jacob, C., Yang, P.-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G. S., Coelho, A.-M., Singh, P., Grady, E. F., Perdue, M. and Bunnett, N. W. (2005) Mast cell tryptase controls paracellular permeability of the intestine: role of protease-activated receptor 2 and beta-arrestins. Journal of Biological Chemistry, 280 (31). pp. 936-948. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M506338200

Dulon, S., Leduc, D., Cottrell, G. S., D'Alayer, J., Hansen, K. K., Bunnett, N. W., Hollenberg, M. D., Pidard, D. and Chignard, M. (2005) Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 32 (5). pp. 411-419. ISSN 1044-1549 doi: https://doi.org/10.1165/rcmb.2004-0274OC

Jacob, C., Cottrell, G. S., Gehringer, D., Schmidlin, F., Grady, E. F. and Bunnett, N. W. (2005) c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. The Journal of Biological Chemistry, 280 (16). pp. 76-87. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M500109200

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., Collins, S. M. and Corinaldesi, R. (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology, 126 (3). pp. 693-702. ISSN 0016-5085 doi: https://doi.org/10.1053/j.gastro.2003.11.055

Amadesi, S., Nie, J., Vergnolle, N., Cottrell, G. S., Grady, E. F., Trevisani, M., Manni, C., Geppetti, P., McRoberts, J. A., Ennes, H., Davis, J. B., Mayer, E. A. and Bunnett, N. W. (2004) Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. The Journal of Neuroscience, 24 (18). pp. 4300-4312. ISSN 1529-2401 doi: https://doi.org/10.1523/JNEUROSCI.5679-03.2004

Roosterman, D., Cottrell, G. S., Schmidlin, F., Steinhoff, M. and Bunnett, N. W. (2004) Recycling and resensitization of the neurokinin 1 receptor: influence of agonist concentration and Rab GTPases. The Journal of Biological Chemistry, 279 (29). pp. 30670-30679. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M402479200

Cottrell, G. S., Amadesi, S., Grady, E. F. and Bunnett, N. W. (2004) Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. Journal of Biological Chemistry, 279 (14). pp. 13532-13539. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M312090200

Reed, D. E., Barajas-Lopez, C., Cottrell, G. S., Velazquez-Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W. and Vanner, S. J. (2003) Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. Journal of Physiology, 547 (2). pp. 531-542. ISSN 0022-3751 doi: https://doi.org/10.1113/jphysiol.2002.032011

Cottrell, G. S., Amadesi, S., Schmidlin, F. and Bunnett, N. (2003) Protease-activated receptor 2: activation, signalling and function. Biochemical Society Transactions, 31 (6). pp. 1191-1197. ISSN 1470-8752

Cottrell, G. S., Coelho, A. M. and Bunnett, N. W. (2002) Protease-activated receptors: the role of cell-surface proteolysis in signalling. Essays in Biochemistry, 38. pp. 169-183. ISSN 0071-1365

Cottrell, G. S., Hooper, N. M. and Turner, A. J. (2000) Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. Biochemistry, 39 (49). pp. 15121-15128. ISSN 0006-2960 doi: https://doi.org/10.1021/bi001585c

Cottrell, G. S., Hyde, R. J., Lim, J., Parsons, M. R., Hooper, N. M. and Turner, A. J. (2000) Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P. Biochemistry, 39 (49). pp. 15129-15135. ISSN 0006-2960 doi: https://doi.org/10.1021/bi0015865

Cottrell, G. S., Hyde, R. J., Hooper, N. M. and Turner, A. J. (1998) The cloning and functional expression of human pancreatic aminopeptidase P. Biochemical Society Transactions, 26 (3). S248. ISSN 1470-8752

Book or Report Section

Cottrell, G. S. (2018) CGRP receptor signalling pathways. In: Handbook of Experimental Pharmacology. Springer. doi: https://doi.org/10.1007/164_2018_130

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