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Personalised nutrition: status and perspectives

Joost, H.G., Gibney, M.J., Cashman, K.D., Gorman, U., Hesketh, J.E., Mueller, M., van Ommen, B., Williams, C.M. and Mathers, J.C. (2007) Personalised nutrition: status and perspectives. British Journal of Nutrition, 98 (1). pp. 26-31. ISSN 0007-1145

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To link to this item DOI: 10.1017/s0007114507685195


Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13268
Uncontrolled Keywords:nutrigenetics, nutrigenomics, nutritional recommendations, genotype, disease risk, BREAST-CANCER RISK, GENETIC POLYMORPHISMS, PROSTATE-CANCER, HEALTH, DISEASE, ASSOCIATION, CHOLESTEROL, GENOMICS, NUTRIGENOMICS, METABOLOMICS

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