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Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain

Fisher, E., Meidtner, K., Angquist, L., Holst, C., Hansen, R. D., Halkjær, J., Masala, G., Ostergaard, J. N., Overvad, K., Palli, D., Vimaleswaran, K. S., Tjønneland, A., van der A, D. L., Wareham, N. J., Sørensen, T. I., Loos, R. J. and Boeing, H. (2012) Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain. American Journal of Clinical Nutrition, 95 (6). pp. 1468-1476. ISSN 0002-9165

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To link to this item DOI: 10.3945/ajcn.111.014670


BACKGROUND: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. OBJECTIVE: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). DESIGN: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition. Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. RESULTS: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. CONCLUSION: TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:34648
Publisher:American Society for Nutrition

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