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Triacylglycerol-rich lipoprotein-gene interactions in endothelial cells

Williams, C. M., Maitin, V. and Jackson, K. G. ORCID: (2004) Triacylglycerol-rich lipoprotein-gene interactions in endothelial cells. Biochemical Society Transactions, 32 (6). pp. 994-998. ISSN 1470-8752

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Lipoproteins such as LDL (low-density lipoprotein) and oxidized LDL have potentially adverse effects on endothelial cells due to their ability to activate pro-inflammatory pathways regulated via the transcription factor NF-kappaB (nuclear factor kappaB). Triacylglycerol-rich lipoproteins (the chylomicrons, very-low-density lipoprotein and their respective remnant particles) have also been implicated in the induction of a pro-inflammatory phenotype and up-regulation of adhesion molecule expression. Although early studies supported the proposal that LPL (lipoprotein lipase)-mediated hydrolysis of TRLs (triglyceride-rich lipoproteins) at the endothelium could activate the NFkappaB pathway, more recent studies provide evidence of pro-and anti-inflammatory responses when cells are exposed to fatty acids of TRL particles. A large number of genes are up- and down-regulated when cells are exposed to TRL, with the net effect reflecting receptor- and nonreceptor-mediated pathways that are activated or inhibited depending on fatty acid type, the lipid and apolipoprotein composition of the TRL and the presence or absence of LPL. Early concepts of TRL particles as essentially pro-inflammatory stimuli to the endothelium provide an overly simplistic view of their impact on the vascular compartment.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:5970
Uncontrolled Keywords:adhesion molecule dietary lipid triacylglycerol-rich lipoprotein endothelial cell LEUKOCYTE ADHESION MOLECULES FACTOR-KAPPA-B E-SELECTIN LINOLEIC-ACID FATTY-ACIDS P-SELECTIN ATHEROSCLEROSIS DYSFUNCTION EXPRESSION VCAM-1
Publisher:Portland Press

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