Number of items: 34.
Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Cox, R. D., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Sellayah, D. and Hughes, C. ORCID: https://orcid.org/0000-0002-9790-5820
(2021)
Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring.
Scientific Reports, 11.
1473.
ISSN 2045-2322
doi: https://doi.org/10.1038/s41598-020-80373-3
Soriano Jerez, E. M., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2021)
Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B.
Platelets, 32 (6).
pp. 761-769.
ISSN 0953-7104
doi: https://doi.org/10.1080/09537104.2021.1882668
Nicolson, P. L., Nock, S. H., Hinds, J., Garcia-Quintanilla, L., Smith, C. W., Campos, J., Brill, A., Pike, J. A., Khan, A. O., Poulter, N. S., Kavanagh, D. M., Watson, S., Watson, C. N., Clifford, H., Huissoon, A. P., Pollitt, A. Y., Eble, J. A., Pratt, G., Watson, S. P. and Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2020)
Low dose Btk inhibitors selectively block platelet activation by CLEC-2.
Haematologica, 105 (1).
ISSN 1592-8721
doi: https://doi.org/10.3324/haematol.2019.218545
Nicolson, P. L. R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Watson, S., Nock, S. H., Hardy, A. T., Watson, C. N., Montague, S. J., Clifford, H., Huissoon, A. P., Malcor, J.-D., Thomas, M. R., Pollitt, A. Y., Tomlinson, M. G., Pratt, G. and Watson, S. P.
(2018)
Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI.
Haematologica, 103 (12).
pp. 2097-2108.
ISSN 1592-8721
doi: https://doi.org/10.3324/haematol.2018.193391
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2018)
How to perform aggregometry and lumi-aggregometry in mouse platelets.
Platelets, 29 (7).
pp. 638-643.
ISSN 0953-7104
doi: https://doi.org/10.1080/09537104.2018.1478074
Mangin, P. H., Onselaer, M.-B., Receveur, N., Le Lay, N., Hardy, A. T., Wilson, C., Sanchez, X., Loyau, S., Dupuis, A., Babar, A. K., Miller, J. L. C., Philippou, H., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Herr, A. B., Ariens, R. A., Mezzano, D., Jandrot-Perrus, M., Gachet, C. and Watson, S. P.
(2018)
Immobilized fibrinogen activates human platelets through GPVI.
Hematologica, 103 (5).
pp. 898-907.
ISSN 1592-8721
doi: https://doi.org/10.3324/haematol.2017.182972
Lombard, S. E., Pollitt, A. Y., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Di, Y., Mckinnon, T., O'Callaghan, C. A. and Watson, S. P.
(2018)
Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis.
Platelets, 29 (7).
pp. 716-722.
ISSN 0953-7104
doi: https://doi.org/10.1080/09537104.2017.1356919
Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Desborough, M. J., Hildyard, C. A. T., Appleby, N., Bruce, D., Kriek, N., Nock, S. H., Sage, T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352
(2017)
Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib.
Blood Advances, 1 (26).
pp. 2610-2623.
ISSN 2473-9529
doi: https://doi.org/10.1182/bloodadvances.2017011999
Alshehri, O. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Montague, S., Watson, S. K., Frampton, J., Bender, M. and Watson, S. P.
(2015)
Fibrin activates GPVI in human and mouse platelets.
Blood, 126 (13).
pp. 1601-1608.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2015-04-641654
Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L. C., Herr, A. B., Pollitt, A. Y., O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P.
(2015)
Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Biochemical Journal, 468 (3).
pp. 459-473.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20150192
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Finney, B. A., Koentgen, F., Lowe, K. L. and Watson, S. P.
(2015)
The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.
Blood, 125 (1).
pp. 144-154.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2014-05-579375
Cherpokova, D., Bender, M., Morowski, M., Kraft, P., Schuhmann, M. K., Akbar, S. M., Sultan, C. S., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Kleinschnitz, C., Stoll, G., Dragone, L. L., Watson, S. P., Tomlinson, M. G. and Nieswandt, B.
(2015)
SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
Blood, 125 (1).
pp. 185-194.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2014-06-580597
Pollitt, A. Y., Poulter, N. S., Gitz, E., Navarro-Nuñez, L., Wang, Y.-J., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Thomas, S. G., Nieswandt, B., Douglas, M. R., Owen, D. M., Jackson, D. G., Dustin, M. L. and Watson, S. P.
(2014)
Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.
The Journal of Biological Chemistry, 289 (52).
pp. 35695-35710.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M114.584284
Dütting, S., Vögtle, T., Morowski, M., Schiessl, S., Schäfer, C. M., Watson, S. K., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Ackermann, J. A., Radtke, D., Hermanns, H. M., Watson, S. P., Nitschke, L. and Nieswandt, B.
(2014)
Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.
Circulation Research, 114 (3).
pp. 444-453.
ISSN 0009-7330
doi: https://doi.org/10.1161/CIRCRESAHA.114.302670
Yu, T. Y., Finney, B. A., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Dehghani, H., Claridge, E. and Thomas, S. G.
(2013)
Three dimensional analysis of cardiovascular development in mouse embryos using X-ray microcomputed tomography.
In: Microscopy and Analysis.
Manne, B. K., Getz, T. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Alshehri, O., Dangelmaier, C., Naik, U. P., Watson, S. P. and Kunapuli, S. P.
(2013)
Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2).
The Journal of Biological Chemistry, 288 (11).
pp. 7717-7726.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M112.424473
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Sinha, U., Pandey, A., Eble, J. A., O'Callaghan, C. A. and Watson, S. P.
(2013)
Critical role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).
The Journal of Biological Chemistry, 288 (7).
pp. 5127-5135.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M112.411462
Pollitt, A. Y., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P.
(2013)
GPVI and CLEC-2.
In: Michelson, A. D. (ed.)
Platelets. 3rd edition.
Academic Press, Amsterdam, pp. 215-231.
ISBN 9780123878373
doi: https://doi.org/10.1016/B978-0-12-387837-3.00011-0
Finney, B. A., Schweighoffer, E., Navarro-Núñez, L., Bénézech, C., Barone, F., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Langan, S. A., Lowe, K. L., Pollitt, A. Y., Mourao-Sa, D., Sheardown, S., Nash, G. B., Smithers, N., Reis e Sousa, C., Tybulewicz, V. L. J. and Watson, S. P.
(2012)
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Blood, 119 (7).
pp. 1747-1756.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2011-09-380709
Jarvis, G. E., Bihan, D., Hamaia, S., Pugh, N., Ghevaert, C. J. G., Pearce, A. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Watson, S. P., Ware, J., Rudd, C. E. and Farndale, R. W.
(2012)
A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).
Journal of Thrombosis and Haemostasis, 10 (2).
pp. 268-277.
ISSN 1538-7933
doi: https://doi.org/10.1111/j.1538-7836.2011.04567.x
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Radhakrishnan, U. P., Lordkipanidzé, M., Egginton, S., Dijkstra, J. M., Jagadeeswaran, P. and Watson, S. P.
(2012)
G6f-like is an ITAM-containing collagen receptor in thrombocytes.
PLoS ONE, 7 (12).
e52622.
ISSN 1932-6203
doi: https://doi.org/10.1371/journal.pone.0052622
Brazón, J., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Mori, J., Sevcik, C., D'suze, G. and Watson, S. P.
(2011)
Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway.
Platelets, 22 (3).
pp. 165-172.
ISSN 0953-7104
doi: https://doi.org/10.3109/09537104.2010.544343
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Navarro-Núñez, L., Finney, B. A., Mourão-Sá, D., Pollitt, A. Y. and Watson, S. P.
(2010)
CLEC-2 is not required for platelet aggregation at arteriolar shear.
Journal of Thrombosis and Haemostasis, 8 (10).
pp. 2328-2332.
ISSN 1538-7933
doi: https://doi.org/10.1111/j.1538-7836.2010.04006.x
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Pollitt, A. Y., Mori, J., Eble, J. A., Tomlinson, M. G., Hartwig, J. H., O'Callaghan, C. A., Fütterer, K. and Watson, S. P.
(2010)
CLEC-2 activates Syk through dimerization.
Blood, 115 (14).
pp. 2947-2955.
ISSN 1528-0020
doi: https://doi.org/10.1182/blood-2009-08-237834
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2010)
Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins.
PhD thesis, University of Birmingham.
Spalton, J. C., Mori, J., Pollitt, A. Y., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Eble, J. A. and Watson, S. P.
(2009)
The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.
Journal of thrombosis and haemostasis : JTH, 7 (7).
pp. 1192-9.
ISSN 1538-7836
Grygielska, B., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P.
(2009)
Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide.
Journal of thrombosis and haemostasis : JTH, 7 (2).
pp. 339-46.
ISSN 1538-7836
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Auger, J. M., McGlade, J., Eble, J. A., Pearce, A. C. and Watson, S. P.
(2008)
Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
Journal of thrombosis and haemostasis : JTH, 6 (12).
pp. 2152-9.
ISSN 1538-7836
Riba, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Graham, A., Watson, S. P. and Naseem, K. M.
(2008)
Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex.
Journal of thrombosis and haemostasis : JTH, 6 (6).
pp. 1012-20.
ISSN 1538-7836
Pears, C. J., Thornber, K., Auger, J. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Grygielska, B., Protty, M. B., Pearce, A. C. and Watson, S. P.
(2008)
Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets.
PLoS ONE, 3 (11).
e3793.
ISSN 1932-6203
doi: https://doi.org/10.1371/journal.pone.0003793
Hughan, S. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, McCarty, O. J. T., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V. L. J. and Watson, S. P.
(2007)
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
Arteriosclerosis, thrombosis, and vascular biology, 27 (2).
pp. 422-9.
ISSN 1524-4636
Dhanjal, T. S., Ross, E. A., Auger, J. M., McCarty, O. J. T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Senis, Y. A., Buckley, C. D. and Watson, S. P.
(2007)
Minimal regulation of platelet activity by PECAM-1.
Platelets, 18 (1).
pp. 56-67.
ISSN 0953-7104
Suzuki-Inoue, K., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Inoue, O., Kaneko, M., Cuyun-Lira, O., Takafuta, T., Watson, S. P. and Ozaki, Y.
(2007)
Involvement of Src kinases and PLCgamma2 in clot retraction.
Thrombosis research, 120 (2).
pp. 251-8.
ISSN 0049-3848
García, A., Senis, Y. A., Antrobus, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Dwek, R. A., Watson, S. P. and Zitzmann, N.
(2006)
A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.
Proteomics, 6 (19).
pp. 5332-43.
ISSN 1615-9853
This list was generated on Wed Apr 24 19:46:53 2024 UTC.