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Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

Spencer, J. P. E., Mohsen, M. M. A., Minihane, A. M. and Mathers, J. C. (2008) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. British Journal of Nutrition, 99 (1). pp. 12-22. ISSN 0007-1145

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To link to this article DOI: 10.1017/s0007114507798938

Abstract/Summary

In order to establish firm evidence for the health effects of dietary polyphenol consumption, it is essential to have quantitative information regarding their dietary intake. The usefulness of the current methods, which rely mainly on the assessment of polyphenol intake using food records and food composition tables, is limited as they fail to assess total intake accurately. This review highlights the problems associated with such methods with regard to polyphenol-intake predictions. We suggest that the development of biological biomarkers, measured in both blood and urine, are essential for making accurate estimates of polyphenol intake. However, the relationship between dietary intakes and nutritional biomarkers are often highly complex. This review identifies the criteria that must be considered in the development of such biomarkers. In addition, we provide an assessment of the limited number of potential biomarkers of polyphenol intake currently available.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:12969
Uncontrolled Keywords:polyphenol, flavonoid, phenolic acid, biomarker, human subjects, metabolism, PLANT-BASED DIETS, HUMAN PLASMA, RED WINE, GASTROINTESTINAL-TRACT, QUERCETIN GLYCOSIDES, TEA CATECHINS, IN-VIVO, ISOFLAVONE GENISTEIN, PHENOLIC-COMPOUNDS, URINARY-EXCRETION
Publisher:Cambridge University Press

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