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Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts

Basu-Modak, S., Gordon, M.J., Dobson, L.H., Spencer, J., Rice-Evans, C. and Tyrrell, R.M. (2003) Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts. Free Radical Biology and Medicine, 35 (8). pp. 910-921. ISSN 0891-5849

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To link to this article DOI: 10.1016/S0891-5849(03)00436-2

Abstract/Summary

The ultraviolet A component of sunlight causes both acute and chronic damage to human skin. In this study the potential of epicatechin, an abundant dietary flavanol, and 3'-O-methyl epicatechin, one of its major in vivo metabolites, to protect against UVA-induced damage was examined using cultured human skin fibroblasts as an in vitro model. The results obtained clearly show that both epicatechin and its metabolite protect these fibroblasts against UVA damage and cell death. The hydrogen-donating antioxidant properties of these compounds are probably not the mediators of this protective response. The protection is a consequence of induction of resistance to UVA mediated by the compounds and involves newly synthesized proteins. The study provides clear evidence that this dietary flavanol has the potential to protect human skin against the deleterious effects of sunlight.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:18617
Uncontrolled Keywords:Catechin/*analogs & derivatives/*pharmacology Cell Division/drug effects/radiation effects Cell Survival Cells, Cultured Fibroblasts/*drug effects/metabolism/radiation effects Heme Oxygenase (Decyclizing)/genetics/metabolism Heme Oxygenase-1 Humans Membrane Proteins Oxidative Stress/*radiation effects RNA, Messenger/genetics/metabolism Reverse Transcriptase Polymerase Chain Reaction Skin/*drug effects/metabolism/radiation effects *Ultraviolet Rays
Additional Information:Basu-Modak, Sharmila Gordon, Matthew J Dobson, Laura H Spencer, Jeremy P E Rice-Evans, Catherine Tyrrell, Rex M Research Support, Non-U.S. Gov't United States Free radical biology & medicine Free Radic Biol Med. 2003 Oct 15;35(8):910-21.
Publisher:Elsevier

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