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The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion

Miller, R., Jackson, K. G., Dadd, T., Mayes, A.E., Brown, L., Lovegrove, J. A. and Minihane, A. M. (2012) The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Molecular Nutrition & Food Research, 56 (6). pp. 966-975. ISSN 1613-4133

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To link to this article DOI: 10.1002/mnfr.201100726

Abstract/Summary

SCOPE: Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green tea extract ingestion are reported. METHODS AND RESULTS: Fifty subjects (n = 25 of the proposed low-activity [AA] and of the high-activity [GG] COMT rs4680 genotype), completed a randomized, double-blind, crossover study. Peripheral arterial tonometry, digital volume pulse (DVP), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index (p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo (p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration (p = 0.049). CONCLUSION: Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:27765
Uncontrolled Keywords:Blood pressure;Catechol-O-methyltransferase;Endothelial function;Flavonoids;Green tea
Publisher:Wiley

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