Accessibility navigation


Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects

Perez-Martinez , P., Garcia-Rios , A., Delgado-Lista , J., Gjelstad, I. M. F., Gibney, J., Kieć-Wilk , B., Camargo, A., Helal , O., Karlström , B., Blaak , E. E., Hall, W., Risérus , U., Dembińska-Kieć , A., Defoort , C., Saris, W. H. M., Lovegrove, J. A., Drevon, C. A., Roche, H. M. and Lopez-Miranda , J. (2013) Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects. Clinical Nutrition, 32 (4). pp. 630-635. ISSN 0261-5614

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/j.clnu.2012.10.003

Abstract/Summary

Genetic background may interact with habitual dietary fat composition, and affect development of the metabolic syndrome (MetS). The phosphoenolpyruvate carboxykinase gene (PCK1) plays a significant role regulating glucose metabolism, and fatty acids are key metabolic regulators, which interact with transcription factors and influence glucose metabolism. We explored genetic variability at the PCK1 gene locus in relation to degree of insulin resistance and plasma fatty acid levels in MetS subjects. Moreover, we analyzed the PCK1 gene expression in the adipose tissue of a subgroup of MetS subjects according to the PCK1 genetic variants.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:31229
Publisher:Elsevier

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation