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Genome-wide association study of response to cognitive behavioural therapy in children with anxiety disorders

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Coleman, J. R. I., Lester, K. J., Keers, R., Roberts, S., Curtis, C., Arendt, K., Bogels, S., Cooper, P., Creswell, C., Dalgleish, T., Hartman, C. A., Heiervang, E. R., Hotzel, K., Hudson, J. L., In-Albon, T., Lavallee, K., Lyneham, H. J., Marin, C. E., Meiser-Stedman, R., Morris, T., Nauta, M. H., Rapee, R. M., Schneider, S., Schneider, S. C., Silverman, W. K., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G. J., Breen, G. and Eley, T. C. (2016) Genome-wide association study of response to cognitive behavioural therapy in children with anxiety disorders. British Journal of Psychiatry, 209 (3). pp. 236-243. ISSN 1472-1465

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To link to this item DOI: 10.1192/bjp.bp.115.168229

Abstract/Summary

Background Anxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent. Aims To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980). Method Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up. Results No variants passed a genome-wide significance threshold (P = 5×10−8) in either analysis. Four variants met criteria for suggestive significance (P<5×10−6) in association with response post-treatment, and three variants in the 6-month follow-up analysis. Conclusions This is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Development
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Anxiety and Depression in Young People (AnDY)
ID Code:51840
Publisher:Royal College of Psychiatrists

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