Number of items: 107.
Article
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Amadi, S. U., Smith, S. J. and Sugden, P. H.
(2024)
Inhibiting the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in cancer and the heart: for better or worse, in sickness and health?
International Journal of Drug Discovery and Pharmacology.
ISSN 2653-6234
doi: https://doi.org/10.53941/ijddp.2024.100006
Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Chothani, S. P., Rackham, O. J. L., Meijles, D., Dash, P. R., Kerkelä, R., Ruparelia, N., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2024)
Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.
Clinical Science, 138 (10).
pp. 573-597.
ISSN 1470-8736
doi: https://doi.org/10.1042/CS20240496
Alharbi, H. O., Hardyman, M. A., Cull, J. J., Markou, T., Cooper, S. T. E., Glennon, P. E., Fuller, S. J., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2022)
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.
Clinical Science, 136 (22).
pp. 1661-1681.
ISSN 0143-5221
doi: https://doi.org/10.1042/CS20220607
Marshall, J. J. T., Cull, J. J., Alharbi, H. O., Zaw Thin, M., Cooper, S. T. E., Barrington, C., Vanyai, H., Snoeks, T., Siow, B., Suáarez-Bonnet, A., Herbert, E., Stuckey, D. J., Cameron, A. J. M., Prin, F., Cook, A. C., Priestnall, S. L., Chotani, S., Rackham, O. J. L., Meijles, D. N., Mohun, T., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Parker, P. J.
(2022)
PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses.
Biochemical Journal, 479 (13).
pp. 1467-1486.
ISSN 1470-8728
doi: https://doi.org/10.1042/BCJ20220281
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Meijles, D. N., Hardyman, M. A., Fuller, S. J., Chothani, S. P., Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Vanezis, K., Felkin, L. E., Markou, T., Leonard, S. J., Shaw, S. W., Rackham, O. J. L., Cook, S. A., Glennon, P. E., Sheppard, M. N., Sembrat, J. C., Rojas, M., McTiernan, C. F., Barton, P. J. and Sugden, P. H.
(2022)
Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Biochemical Journal, 479 (3).
pp. 401-424.
ISSN 0264-6021
doi: https://doi.org/10.1042/BCJ20210615
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2022)
The insulin receptor family in the heart: new light on old insights.
Bioscience reports, 42 (7).
BSR20221212.
ISSN 1573-4935
doi: https://doi.org/10.1042/BSR20221212
Meijles, D. N., Cull, J. J., Cooper, S. T. E., Markou, T., Hardyman, M. A., Fuller, S. J., Alharbi, H. O., Haines, Z. H. R., Alcantara Alonso, V.
ORCID: https://orcid.org/0000-0002-9782-2398, Glennon, P. E., Sheppard, M. N., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2021)
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
Clinical Science, 135 (14).
pp. 1631-1647.
ISSN 0143-5221
doi: https://doi.org/10.1042/CS20210192
Meijles, D. N., Fuller, S. J., Cull, J. J., Alharbi, H. O., Cooper, S. T. E., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2021)
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.
Biochemical Journal, 478 (11).
pp. 2059-2079.
ISSN 1470-8728
doi: https://doi.org/10.1042/BCJ20210144
Fuller, S. J., Edmunds, N. S., McGuffin, L. J.
ORCID: https://orcid.org/0000-0003-4501-4767, Hardyman, M. A., Cull, J. J., Alharbi, H. O., Meijles, D. N., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2021)
MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins.
Biochemical Journal, 478 (11).
pp. 2121-2143.
ISSN 0264-6021
doi: https://doi.org/10.1042/BCJ20210003
Meijles, D. N., Cull, J. J., Markou, T., Cooper, S. T. E., Haines, Z. H. R., Fuller, S. J., O'Gara, P., Sheppard, M. N., Harding, S. E., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2020)
Redox regulation of cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) controls p38-MAPK (Mitogen-Activated Protein Kinase) and orchestrates cardiac remodelling to hypertension.
Hypertension, 76 (4).
pp. 1208-1218.
ISSN 1524-4563
doi: https://doi.org/10.1161/HYPERTENSIONAHA.119.14556
Meijles, D. N., Zoumpoulidou, G., Markou, T., Rostron, K. A., Patel, R., Lay, K., Handa, B. S., Wong, B., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2019)
The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.
Journal of molecular and cellular cardiology, 129.
pp. 118-129.
ISSN 1095-8584
doi: https://doi.org/10.1016/j.yjmcc.2019.02.006
Fuller, S. J., Osborne, S. A., Leonard, S. J., Hardyman, M. A., Vaniotis, G., Allen, B. G., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2015)
Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.
Cardiovascular Research, 108 (1).
pp. 87-98.
ISSN 0008-6363
doi: https://doi.org/10.1093/cvr/cvv210
Tindall, M. J. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2014)
Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation.
PLoS Computational Biology, 10 (5).
e1003597.
ISSN 1553-734X
doi: https://doi.org/10.1371/journal.pcbi.1003597
Leite-Moreira, A. F., Lourenço, A. P., Balligand, J.-L., Bauersachs, J., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, De Windt, L. J., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Kaminski, K. A., Knöll, R., Mayr, M., Tarone, G., Thum, T. and Tocchetti, C. G.
(2014)
ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.
European Journal of Heart Failure, 16 (5).
pp. 509-18.
ISSN 1879-0844
doi: https://doi.org/10.1002/ejhf.66
Tarone, G., Balligand, J.-L., Bauersachs, J., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, De Windt, L., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Knöll, R., Leite-Moreira, A. F., Lourenço, A. P., Mayr, M., Thum, T. and Tocchetti, C. G.
(2014)
Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.
European Journal of Heart Failure, 16 (5).
pp. 494-508.
ISSN 1879-0844
doi: https://doi.org/10.1002/ejhf.62
Sugden, P. H., McGuffin, L. J.
ORCID: https://orcid.org/0000-0003-4501-4767 and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2013)
SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions.
Biochemical Journal, 454 (1).
pp. 13-30.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20130219
Barrett, O. P. T., Yndestad, A., Marshall, A. K., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2013)
The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.
Cytokine, 61 (2).
pp. 340-344.
ISSN 1096-0023
doi: https://doi.org/10.1016/j.cyto.2012.11.004
Amirak, E., Fuller, S. J., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2013)
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists.
Biochemical Journal, 450 (2).
pp. 351-363.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20121371
Giraldo, A., Barrett, O. P. T., Tindall, M. J., Fuller, S. J., Amirak, E., Bhattacharya, B. S., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2012)
Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target.
Biochemical Journal, 444 (2).
pp. 343-355.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20120125
Fuller, S. J., McGuffin, L. J.
ORCID: https://orcid.org/0000-0003-4501-4767, Marshall, A. K., Giraldo, A., Pikkarainen, S., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P.
(2012)
A novel, non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Biochemical Journal, 442 (3).
pp. 595-610.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20112000
Sugden, P. H., Markou, T., Fuller, S. J., Tham, E. L., Molkentin, J. D., Paterson, H. F. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2011)
Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.
Cellular Signalling, 23 (2).
pp. 468-477.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2010.10.024
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2010)
Dying by the way you live: AIF vs. caspases in apoptosis of hypertrophied cardiomyocytes.
Cardiovascular research, 85 (1).
pp. 3-4.
ISSN 1755-3245
Marshall, A. K., Barrett, O. P. T., Cullingford, T. E., Shanmugasundram, A., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2010)
ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
PLoS ONE, 5 (4).
e10027.
ISSN 1932-6203
doi: https://doi.org/10.1371/journal.pone.0010027
Yndestad, A., Marshall, A. K., Hodgkinson, J. D., Tham, E. L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2010)
Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.
International Journal of Biochemistry & Cell Biology, 42 (2).
pp. 263-272.
ISSN 1357-2725
doi: https://doi.org/10.1016/j.biocel.2009.10.021
Markou, T., Marshall, A. K., Cullingford, T. E., Tham, E. L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2010)
Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.
BMC Genomics, 11.
343.
ISSN 1471-2164
doi: https://doi.org/10.1186/1471-2164-11-343
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Fuller, S. J., Giraldo, A. and Sugden, P. H.
(2009)
Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2.
Advances in Enzyme Regulation, 49 (1).
pp. 30-42.
ISSN 0065-2571
doi: https://doi.org/10.1016/j.advenzreg.2008.12.007
Pikkarainen, S., Kennedy, R. A., Marshall, A. K., Tham, E. L., Lay, K., Kriz, T. A., Handa, B. S., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2009)
Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H2O2-induced oxidative stress in neonatal rat cardiac myocytes.
The Journal of Biological Chemistry, 284 (40).
pp. 27195-27210.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M109.037887
Cook, S. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2008)
Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?
Journal of Molecular and Cellular Cardiology, 46 (2).
pp. 118-129.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2008.11.005
Cullingford, T. E., Butler, M. J., Marshall, A. K., Tham, E. L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2008)
Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines.
Biochimica Et Biophysica Acta-Molecular Cell Research, 1783 (6).
pp. 1229-1236.
ISSN 0167-4889
doi: https://doi.org/10.1016/j.bbamcr.2008.03.007
Sugden, P. H., Fuller, S. J., Weiss, S. C. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2008)
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.
British Journal of Pharmacology, 153 (S1).
S137-S153.
ISSN 1476-5381
doi: https://doi.org/10.1038/sj.bjp.0707659
Prasad, S. K., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Chen, A. W. Y., Kemp, T. J., Cannell, T. M., Cowie, M. R. and Petrou, M.
(2008)
Gene expression profiling of human hibernating myocardium: Increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart.
European Journal of Heart Failure, 10 (12).
pp. 1177-1180.
ISSN 1388-9842
doi: https://doi.org/10.1016/j.ejheart.2008.08.008
Markou, T., Cullingford, T. E., Giraldo Ramirez, A., Weiss, S. C., Alsafi, A., Fuller, S. J., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2008)
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition.
Cellular Signalling, 20 (1).
pp. 206-218.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2007.10.004
Fuller, S. J., Pikkarainen, S., Tham, E. L., Cullingford, T. E., Molkentin, J. D., Cornils, H., Hergovitch, A., Hemmings, B. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2008)
Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.
Cellular Signalling, 20 (8).
pp. 1564-1577.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2008.04.013
Cullingford, T. E., Markou, T., Fuller, S. J., Giraldo, A., Pikkarainern, S., Zoumpoulidou, G., Alsafi, A., Ekere, C., Kemp, T. J., Dennis, J. L., Game, L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2008)
Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes.
Genome Biology, 9 (2).
R32.
ISSN 1474-760X
doi: https://doi.org/10.1186/gb-2008-9-2-r32
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Fuller, S. J., Giraldo, A., Markou, T., Pikkarainen, S. and Sugden, P.
(2007)
Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses.
Journal of cellular physiology, 212 (2).
pp. 311-322.
ISSN 0021-9541
doi: https://doi.org/10.1002/jcp.21094
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Zoumpoulidou, G. and Sugden, P.
(2007)
Cardiac myocyte gene expression profiling during H2O2-induced apoptosis.
Physiological genomics, 29 (2).
pp. 118-127.
ISSN 1531-2267
doi: https://doi.org/10.1152/physiolgenomics.00168.2006
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Giraldo, A. and Sugden, P.
(2007)
Chemotherapeutic agents and gene expression in cardiac myocytes.
Advances in Enzyme Regulation, 47 (1).
pp. 140-153.
ISSN 0065-2571
doi: https://doi.org/10.1016/j.advenzreg.2006.12.004
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2006)
Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes.
Antioxidants & Redox Signaling, 8 (11-12).
pp. 2111-2124.
ISSN 1523-0864
doi: https://doi.org/10.1089/ars.2006.8.2111
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P.
(2006)
Ras: the stress and the strain.
Journal of Molecular and Cellular Cardiology, 41 (4).
pp. 595-600.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2006.06.075
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P.
(2006)
Inflame my heart (by p38-MAPK).
Circulation Research, 99 (5).
pp. 455-458.
ISSN 0009-7330
doi: https://doi.org/10.1161/01.RES.0000241053.89089.c3
Kennedy, R. A., Kemp, T. J., Sugden, P. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2006)
Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.
Journal of Molecular and Cellular Cardiology, 41 (2).
pp. 236-247.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2006.04.011
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Aggeli, I.-K. S., Stathopoulou, K. and Sugden, P. H.
(2006)
Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes.
Cellular Signalling, 18 (2).
pp. 225-235.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2005.04.005
Cullingford, T. E., Wait, R., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2006)
Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins.
Journal of Molecular and Cellular Cardiology, 40 (1).
pp. 157-172.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2005.10.004
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2005)
Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.
Current vascular pharmacology, 3 (4).
pp. 343-351.
ISSN 1570-1611
doi: https://doi.org/10.2174/157016105774329390
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Kemp, T. J., Kennedy, R. A. and Sugden, P. H.
(2005)
Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis.
Advances in Enzyme Regulation, 45 (1).
pp. 94-111.
ISSN 0065-2571
doi: https://doi.org/10.1016/j.advenzreg.2005.02.007
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2004)
Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 82 (6).
pp. 603-9.
ISSN 0829-8211
Kemp, T. J., Aggeli, I.-K., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2004)
Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes.
Journal of molecular and cellular cardiology, 37 (2).
pp. 603-6.
ISSN 0022-2828
Harrison, J. G., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2004)
Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression.
Biochimica et biophysica acta, 1644 (1).
pp. 17-25.
ISSN 0006-3002
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Harrison, J. G., Pham, F. H. and Sugden, P. H.
(2004)
Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases.
Advances in enzyme regulation, 44.
pp. 233-48.
ISSN 0065-2571
Kemp, T. J., Causton, H. C. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2003)
Changes in gene expression induced by H(2)O(2) in cardiac myocytes.
Biochemical and biophysical research communications, 307 (2).
pp. 416-21.
ISSN 0006-291X
Valks, D. M., Kemp, T. J. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2003)
Regulation of Bcl-xL expression by H2O2 in cardiac myocytes.
The Journal of biological chemistry, 278 (28).
pp. 25542-7.
ISSN 0021-9258
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2003)
The radical balance between life and death.
Journal of molecular and cellular cardiology, 35 (6).
pp. 599-602.
ISSN 0022-2828
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cole, S. M., Cullingford, T. E., Harrison, J. G., Jormakka, M. and Valks, D. M.
(2003)
Regulation of cardiac myocyte cell death.
Pharmacology & therapeutics, 97 (3).
pp. 223-61.
ISSN 0163-7258
Vlahos, C. J., McDowell, S. A. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2003)
Kinases as therapeutic targets for heart failure.
Nature reviews. Drug discovery, 2 (2).
pp. 99-113.
ISSN 1474-1776
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Harrison, J. G., Mullen, A. J., Barton, P. J. R. and Sugden, P. H.
(2002)
Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.
The Biochemical journal, 368 (Pt 1).
pp. 101-10.
ISSN 0264-6021
Valks, D. M., Cook, S. A., Pham, F. H., Morrison, P. R., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2002)
Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A.
Journal of molecular and cellular cardiology, 34 (7).
pp. 749-63.
ISSN 0022-2828
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2001)
Untangling the Web: specific signaling from PKC isoforms to MAPK cascades.
Circulation research, 89 (10).
pp. 847-9.
ISSN 1524-4571
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2001)
Death by protein kinase C inhibitor: a stressful event.
Journal of molecular and cellular cardiology, 33 (10).
pp. 1773-6.
ISSN 0022-2828
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2001)
Akt like a woman: gender differences in susceptibility to cardiovascular disease.
Circulation research, 88 (10).
pp. 975-7.
ISSN 1524-4571
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Pham, F. H., Fuller, S. J., Sahai, E., Aktories, K., Marais, R., Marshall, C. and Sugden, P. H.
(2001)
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1.
Molecular and cellular biology, 21 (4).
pp. 1173-84.
ISSN 0270-7306
Pham, F. H., Cole, S. M. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2001)
Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.
Advances in enzyme regulation, 41.
pp. 73-86.
ISSN 0065-2571
Pham, F. H., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2000)
Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes.
Circulation research, 86 (12).
pp. 1252-8.
ISSN 1524-4571
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2000)
Small guanine nucleotide-binding proteins and myocardial hypertrophy.
Circulation research, 86 (10).
pp. 1019-23.
ISSN 1524-4571
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2000)
Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists.
Trends in cardiovascular medicine, 10 (1).
pp. 1-8.
ISSN 1050-1738
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Harrison, J. G., Long, C. S. and Sugden, P. H.
(1999)
Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes.
Journal of molecular and cellular cardiology, 31 (12).
pp. 2087-99.
ISSN 0022-2828
Cook, S. A., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1999)
Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential.
Circulation research, 85 (10).
pp. 940-9.
ISSN 1524-4571
Ping, P., Zhang, J., Huang, S., Cao, X., Tang, X. L., Li, R. C., Zheng, Y. T., Qiu, Y., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Sugden, P., Han, J. and Bolli, R.
(1999)
PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.
The American journal of physiology, 277 (5 Pt 2).
H1771-85.
ISSN 0002-9513
Cook, S. A., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1999)
Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease.
Journal of molecular and cellular cardiology, 31 (8).
pp. 1429-34.
ISSN 0022-2828
Chiloeches, A., Paterson, H. F., Marais, R., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Marshall, C. J. and Sugden, P. H.
(1999)
Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras.
The Journal of biological chemistry, 274 (28).
pp. 19762-70.
ISSN 0021-9258
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1999)
Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists.
The American journal of cardiology, 83 (12A).
64H-69H.
ISSN 0002-9149
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1998)
Cellular mechanisms of cardiac hypertrophy.
Journal of molecular medicine (Berlin, Germany), 76 (11).
pp. 725-46.
ISSN 0946-2716
Haq, S. E., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1998)
Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart.
FEBS letters, 434 (3).
pp. 305-8.
ISSN 0014-5793
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1998)
"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium.
Circulation research, 83 (4).
pp. 345-52.
ISSN 0009-7330
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Michael, A. and Sugden, P. H.
(1998)
Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes.
The Biochemical journal, 333 ( Pt 3.
pp. 581-9.
ISSN 0264-6021
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Michael, A. and Sugden, P. H.
(1998)
Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?
The Journal of cell biology, 142 (2).
pp. 523-35.
ISSN 0021-9525
Lazou, A., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1998)
Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart.
The Biochemical journal, 332 ( Pt 2.
pp. 459-65.
ISSN 0264-6021
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1998)
The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs).
FEBS letters, 426 (1).
pp. 93-6.
ISSN 0014-5793
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Fuller, S. J., Michael, A. and Sugden, P. H.
(1998)
Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses.
The Journal of biological chemistry, 273 (13).
pp. 7228-34.
ISSN 0021-9258
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1998)
Regulation of mitogen-activated protein kinase cascades in the heart.
Advances in enzyme regulation, 38.
pp. 87-98.
ISSN 0065-2571
Sugden, P. H., Fuller, S. J., Michael, A. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1997)
Activation of mitogen-activated protein kinase subfamilies by oxidative stress in the perfused rat heart.
Biochemical Society transactions, 25 (4).
S565.
ISSN 0300-5127
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1997)
Mitogen-activated protein kinases are activated by oxidative stress and cytokines in neonatal rat ventricular myocytes.
Biochemical Society transactions, 25 (4).
S566.
ISSN 0300-5127
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1997)
Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes.
The Biochemical journal, 325 ( Pt 3.
pp. 801-10.
ISSN 0264-6021
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1997)
Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors.
Cellular signalling, 9 (5).
pp. 337-51.
ISSN 0898-6568
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1997)
Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine.
Journal of molecular and cellular cardiology, 29 (6).
pp. 1593-604.
ISSN 0022-2828
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(1997)
Cell stresses regulate the phosphorylation state of c-Jun and ATF2 in ventricular myocytes.
Biochemical Society transactions, 25 (2).
221S.
ISSN 0300-5127
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1997)
Phosphorylation c-Jun and ATF2 in ventricular myocytes by endothelin and phenylephrine.
Biochemical Society transactions, 25 (2).
222S.
ISSN 0300-5127
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1997)
Activation of p21-activated protein kinase alpha (alpha PAK) by hyperosmotic shock in neonatal ventricular myocytes.
FEBS letters, 403 (1).
pp. 23-5.
ISSN 0014-5793
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Gillespie-Brown, J., Fuller, S. J. and Sugden, P. H.
(1996)
Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response.
The Biochemical journal, 317 ( Pt 1.
pp. 109-18.
ISSN 0264-6021
Bogoyevitch, M. A., Andersson, M. B., Gillespie-Brown, J., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Glennon, P. E., Fuller, S. J. and Sugden, P. H.
(1996)
Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy.
The Biochemical journal, 314 ( Pt 1.
pp. 115-21.
ISSN 0264-6021
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Bogoyevitch, M. A., Fuller, S. J., Lazou, A., Parker, P. J. and Sugden, P. H.
(1995)
Expression of protein kinase C isoforms during cardiac ventricular development.
The American journal of physiology, 269 (3 Pt 2).
H1087-97.
ISSN 0002-9513
Bogoyevitch, M. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(1995)
Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes.
The Biochemical journal, 309 ( Pt 2.
pp. 437-43.
ISSN 0264-6021
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Bogoyevitch, M. A., Anderson, M. B. and Sugden, P. H.
(1994)
Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts.
The Journal of biological chemistry, 269 (52).
pp. 32848-57.
ISSN 0021-9258
Lazou, A., Bogoyevitch, M. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Fuller, S. J., Marshall C, J. and Sugden, P. H.
(1994)
Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.
Circulation research, 75 (5).
pp. 932-41.
ISSN 0009-7330
Bogoyevitch, M. A., Glennon, P. E., Andersson, M. B., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Lazou, A., Marshall, C. J., Parker, P. J. and Sugden, P. H.
(1994)
Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.
The Journal of biological chemistry, 269 (2).
pp. 1110-9.
ISSN 0021-9258
Muntoni, F., Mateddu, A., Marchei, F., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Serra, G.
(1993)
Muscular weakness in the mdx mouse.
Journal of the neurological sciences, 120 (1).
pp. 71-7.
ISSN 0022-510X
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Bogoyevitch, M. A., Parker, P. J. and Sugden, P. H.
(1993)
Down-regulation of protein kinase C isotypes during postnatal development of rat heart.
Biochemical Society transactions, 21 (4).
385S.
ISSN 0300-5127
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Morris, G. E., Dubowitz, V., Davies, K. E. and Sewry, C. A.
(1993)
Dystrophin-related protein, utrophin, in normal and dystrophic human fetal skeletal muscle.
The Histochemical journal, 25 (8).
pp. 554-61.
ISSN 0018-2214
Sewry, C. A., Sansome, A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Sherratt, T. G., Hasson, N., Rodillo, E., Heckmatt, J. Z., Strong, P. N. and Dubowitz, V.
(1993)
Manifesting carriers of Xp21 muscular dystrophy; lack of correlation between dystrophin expression and clinical weakness.
Neuromuscular disorders : NMD, 3 (2).
pp. 141-8.
ISSN 0960-8966
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Muntoni, F. and Strong, P. N.
(1993)
A dystrophin-immunoreactive protein in mammalian brain.
Journal of neurochemistry, 60 (2).
pp. 435-41.
ISSN 0022-3042
Muntoni, F., Mateddu, A., Cianchetti, C., Marrosu, M. G., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cau, M., Congiu, R., Cao, A. and Melis, M. A.
(1993)
Dystrophin analysis using a panel of anti-dystrophin antibodies in Duchenne and Becker muscular dystrophy.
Journal of Neurology, Neurosurgery, and Psychiatry, 56 (1).
pp. 26-31.
ISSN 0022-3050
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Sewry, C. A., Dubowitz, V. and Strong, P. N.
(1992)
Characterisation of dystrophin in fetuses at risk for Duchenne muscular dystrophy.
Journal of Neurological Sciences, 111 (1).
pp. 82-91.
ISSN 0022-510X
Torelli, S., Sogos, V., Ennas, M. G., Muntoni, F., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Strong, P. N. and Gremo, F.
(1992)
Dystrophin immunoreactivity in normal and Duchenne human fetal neurons in culture.
Journal of neuroscience research, 32 (1).
pp. 116-25.
ISSN 0360-4012
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Strong, P. N. and Sewry, C. A.
(1992)
Characterisation of dystrophin during development of human skeletal muscle.
Development (Cambridge, England), 114 (2).
pp. 395-402.
ISSN 0950-1991
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Rodillo, E., Heckmatt, J. Z., Dubowitz, V., Strong, P. N. and Sewry, C. A.
(1991)
Characterisation of dystrophin in carriers of Duchenne muscular dystrophy.
Journal of Neurological Sciences, 102 (2).
pp. 197-205.
ISSN 0022-510X
Sewry, C. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Heckmatt, J. Z., Vyse, T., Dubowitz, V. and Strong, P. N.
(1991)
Dystrophin abnormalities in polymyositis and dermatomyositis.
Neuromuscular disorders : NMD, 1 (5).
pp. 333-9.
ISSN 0960-8966
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Muntoni, F. and Strong, P.
(1990)
Dystrophin and dystrophin-like proteins in muscle and brain of normal and mdx mice.
Biochemical Society Transactions, 18 (3).
pp. 388-9.
ISSN 0300-5127
Patent
St George's Hospital Medical School
(2020)
Treatment of fibrosis With RAF inhibitors.
WO 2020/161477.
doi: WO 2020/161477
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