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The neuroprotective potential of flavonoids: a multiplicity of effects

Vauzour, D., Vafeiadou, K., Rodriguez-Mateos, A., Rendeiro, C. and Spencer, J.P.E. (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes and Nutrition, 3 (3-4). pp. 115-126. ISSN 1555-8932

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To link to this article DOI: 10.1007/s12263-008-0091-4

Abstract/Summary

Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. These effects appear to be underpinned by two common processes. Firstly, they interact with critical protein and lipid kinase signalling cascades in the brain leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Secondly, they induce beneficial effects on the vascular system leading to changes in cerebrovascular blood flow capable of causing angiogenesis, neurogenesis and changes in neuronal morphology. Through these mechanisms, the consumption of flavonoid-rich foods throughout life holds the potential to limit neurodegeneration and to prevent or reverse age-dependent loses in cognitive performance. The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:12896
Uncontrolled Keywords:Flavonoid, Brain, Neuroprotection, Neuroinflammation, Memory, Cognitive, function, GINKGO-BILOBA EXTRACT, LOW-DENSITY-LIPOPROTEIN, BLOOD-BRAIN-BARRIER, NITRIC-OXIDE SYNTHASE, FACTOR-KAPPA-B, PROTECTS DOPAMINERGIC-NEURONS, INDUCED MICROGLIAL ACTIVATION, INDUCED LIPID-PEROXIDATION, ARM MAZE, PERFORMANCE, FLAVANOL-RICH COCOA

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