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Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury

Vauzour, D., Vafeiadou, K., Corona, G., Pollard, S. E., Tzounis, X. and Spencer, J. P. E. (2007) Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. Journal of Agricultural and Food Chemistry, 55 (8). pp. 2854-2860. ISSN 0021-8561

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To link to this article DOI: 10.1021/jf063304z

Abstract/Summary

White wines are generally low in polyphenol content as compared to red wines. However, Champagne wines have been shown to contain relatively high amounts of phenolic acids that may exert protective cellular actions in vivo. In this study, we have investigated the potential neuroprotective effects of Champagne wine extracts, and individual phenolics present in these extracts, against peroxynitrite-induced injury. Organic and aqueous Champagne wine extracts exhibited potent neuroprotective activity against peroxynitrite-induced injury at low concentrations (0.1 mu g/mL). This protection appeared to be in part due to the cellular actions of individual components found in the organic extracts, notably tyrosol, caffeic acid, and gallic acid. These phenolics were observed to exert potent neuroprotection at concentrations between 0.1 and 10 mu M. Together, these data suggest that polyphenols present in Champagne wine may induce a neuroprotective effect against oxidative neuronal injury.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:12899
Uncontrolled Keywords:Animals, Brain/cytology, Cells, Cultured Embryo, Mammalian Flavonoids/*pharmacology, Fruit/chemistry, Mice, Neurons/*drug effects, Neuroprotective Agents/*pharmacology, Peroxynitrous Acid/*toxicity, Phenols/*pharmacology, Vitis/chemistry, Wine/*analysiscortical neurons, protective effect, Champagne wine, peroxynitrite, phenolics, in-vivo metabolites, oxidative stress, parkinsons-disease, caffeic, acid, nitric-oxide, flavonoids, nitration, neurodegeneration, antioxidants, inhibition
Additional Information:Research Support, Non-U.S. Gov't United States
Publisher:American Chemical Society

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