Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: the Food4Me study
Celis-Morales, C., Marsaux, C. F.M., Livingstone, K. M., Navas-Carretero, S. , San-Cristobal, R. , O’Donovan, C. B., Forster, H. , Woolhead, C., Fallaize, R., Macready, A. L.  ORCID: https://orcid.org/0000-0003-0368-9336, Kolossa, S. , Hallmann, J. , Tsirigoti, L. , Lambrinou, C. P., Moschonis, G. , Godlewska, M. , Surwiłło, A. , Grimaldi, K. , Bouwman, J. , Manios, Y. et al, Traczyk, I. , Drevon, C. A., Parnell, L. D., Daniel, H. , Gibney, E. R., Brennan, L. , Walsh, M. C., Gibney, M. , Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Martinez, J. A. , Saris, W. H.M. and Mathers, J. C.
(2016)
Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: the Food4Me study.
Obesity, 24 (4).
pp. 962-969.
ISSN 1930-739X
Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1002/oby.21422 Abstract/SummaryObjective: To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.
Methods: Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.
Results: FTO genotype was associated with a higher body weight [b: 1.09 kg per risk allele, (95% CI:0.14-2.04),
P=0.024], BMI [b: 0.54 kg m-2, (0.23-0.83), P<0.0001], and WC [b: 1.07 cm, (0.24-1.90),P=0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P[interaction]=0.020). Among inactive individuals, FTO increased BMI by 1.06 kg m-2 per allele (P=0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kg m-2, P=0.388). We observed similar effects for WC (P[interaction]=0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals.
Conclusions: PA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle. | Funders: |
European Commission
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| Projects: |
Food4Me
Funded by:
European Commission
(FP7-KBBE-2010-4 265494 - £321,916)
Local Lead (PI): Julie Lovegrove
1 April 2011 - 31 March 2015
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| Date Deposited: | 20 Dec 2016 09:21 | Date item deposited into CentAUR |
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| Last Modified: | 14 Apr 2024 02:28 | Date item last modified |
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