1. Batra N, Kar R, Jiang JX. Gap Junctions and Hemichannels in Signal Transmission, Function and Development of Bone. Biochimica et biophysica acta. 2012;1818(8):1909-1918.
2. Goodenough DA, Paul DL. Gap junctions. Cold Spring Harb Perspect Biol. 2009;1(1):a002576.
3. Hanner F, Sorensen CM, Holstein-Rathlou N-H, Peti-Peterdi J. Connexins and the kidney. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2010;298(5):R1143-R1155.
4. Koval M, Molina SA, Burt JM. Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues. FEBS letters. 2014;588(8):1193-1204.
5. Huettner JE, Lu A, Qu Y, Wu Y, Kim M, McDonald JW. Gap junctions and connexon hemichannels in human embryonic stem cells. Stem Cells. 2006;24(7):1654-1667.
6. Kostin S, Dammer S, Hein S, Klovekorn WP, Bauer EP, Schaper J. Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovasc Res. 2004;62(2):426-436.
7. Darrow BJ, Fast VG, Kléber AG, Beyer EC, Saffitz JE. Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996;79(2):174-183.
8. Oyamada M, Kimura H, Oyamada Y, Miyamoto A, Ohshika H, Mori M. The expression, phosphorylation, and localization of connexin 43 and gap-junctional intercellular communication during the establishment of a synchronized contraction of cultured neonatal rat cardiac myocytes. Exp Cell Res. 1994;212(2):351-358.
9. Molica F, Figueroa XF, Kwak BR, Isakson BE, Gibbins JM. Connexins and Pannexins in Vascular Function and Disease. Int J Mol Sci. 2018;19(6).
10. Figueroa XF, Isakson BE, Duling BR. Connexins: gaps in our knowledge of vascular function. Physiology (Bethesda). 2004;19:277-284.
11. Billaud M, Lohman AW, Johnstone SR, Biwer LA, Mutchler S, Isakson BE. Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacological reviews. 2014;66(2):513-569.
12. Kwak BR, Mulhaupt F, Veillard N, Gros DB, Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2002;22(2):225-230.
13. Johnstone SR, Ross J, Rizzo MJ, et al. Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation. The American journal of pathology. 2009;175(2):916-924.
14. Yeh HI, Lu CS, Wu YJ, et al. Reduced expression of endothelial connexin37 and connexin40 in hyperlipidemic mice: recovery of connexin37 after 7-day simvastatin treatment. Arterioscler Thromb Vasc Biol. 2003;23(8):1391-1397.
15. Ilhan F, Kalkanli ST. Atherosclerosis and the role of immune cells. World journal of clinical cases. 2015;3(4):345-352.
16. Ammirati E, Moroni F, Magnoni M, Camici PG. The role of T and B cells in human atherosclerosis and atherothrombosis. Clinical and experimental immunology. 2015;179(2):173-187.
17. Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O. Neutrophils in atherosclerosis. A brief overview. Hamostaseologie. 2015;35(2):121-127.
18. Anand RJ, Dai S, Gribar SC, et al. A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection. J Immunol. 2008;181(12):8534-8543.
19. Sarieddine MZ, Scheckenbach KE, Foglia B, et al. Connexin43 modulates neutrophil recruitment to the lung. J Cell Mol Med. 2009;13(11-12):4560-4570.
20. Machtaler S, Dang-Lawson M, Choi K, Jang C, Naus CC, Matsuuchi L. The gap junction protein Cx43 regulates B-lymphocyte spreading and adhesion. Journal of cell science. 2011;124(15):2611-2621.
21. Vaiyapuri S, Flora GD, Gibbins JM. Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochem Soc Trans. 2015;43(3):489-494.
22. Badimon L, Padró T, Vilahur G. Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. European Heart Journal: Acute Cardiovascular Care. 2012;1(1):60-74.
23. Flora GD, Nayak MK. A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes. Curr Pharm Des. 2019;25(38):4063-4084.
24. Vaiyapuri S, Sage T, Rana RH, et al. EphB2 regulates contact-dependent and contact-independent signaling to control platelet function. Blood. 2015;125(4):720-730.
25. Prevost N, Woulfe D, Tognolini M, Brass LF. Contact-dependent signaling during the late events of platelet activation. J Thromb Haemost. 2003;1(7):1613-1627.
26. Vaiyapuri S, Jones CI, Sasikumar P, et al. Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation. 2012;125(20):2479-2491.
27. Vaiyapuri S, Moraes LA, Sage T, et al. Connexin40 regulates platelet function. Nature communications. 2013;4:2564.
28. Sohl G, Joussen A, Kociok N, Willecke K. Expression of connexin genes in the human retina. BMC Ophthalmol. 2010;10:27.
29. Morel S. Multiple roles of connexins in atherosclerosis- and restenosis-induced vascular remodelling. J Vasc Res. 2014;51(2):149-161.
30. Vaiyapuri S, Roweth H, Ali MS, et al. Pharmacological actions of nobiletin in the modulation of platelet function. Br J Pharmacol. 2015;172(16):4133-4145.
31. Flora GD, Sahli KA, Sasikumar P, et al. Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Sci Rep. 2019;9(1):17210.
32. Unsworth AJ, Flora GD, Sasikumar P, et al. RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arterioscler Thromb Vasc Biol. 2017;37(5):812-822.
33. Sáez JC, Retamal MA, Basilio D, Bukauskas FF, Bennett MV. Connexin-based gap junction hemichannels: gating mechanisms. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2005;1711(2):215-224.
34. Malkusch S, Endesfelder U, Mondry J, Gelleri M, Verveer PJ, Heilemann M. Coordinate-based colocalization analysis of single-molecule localization microscopy data. Histochem Cell Biol. 2012;137(1):1-10.
35. McGuffin LJ, Atkins JD, Salehe BR, Shuid AN, Roche DB. IntFOLD: an integrated server for modelling protein structures and functions from amino acid sequences. Nucleic Acids Res. 2015;43(W1):W169-173.
36. Maghrabi AHA, McGuffin LJ. ModFOLD6: an accurate web server for the global and local quality estimation of 3D protein models. Nucleic Acids Res. 2017;45(W1):W416-w421.
37. Verselis VK, Srinivas M. Connexin channel modulators and their mechanisms of action. Neuropharmacology. 2013;75:517-524.
38. Leybaert L, Braet K, Vandamme W, Cabooter L, Martin PE, Evans WH. Connexin channels, connexin mimetic peptides and ATP release. Cell Commun Adhes. 2003;10(4-6):251-257.
39. Warner TD, Nylander S, Whatling C. Anti‐platelet therapy: cyclo‐oxygenase inhibition and the use of aspirin with particular regard to dual anti‐platelet therapy. British journal of clinical pharmacology. 2011;72(4):619-633.
40. Durrant TN, van den Bosch MT, Hers I. Integrin αIIbβ3 outside-in signaling. Blood. 2017;130(14):1607-1619.
41. Li Z, Delaney MK, O'brien KA, Du X. Signaling during platelet adhesion and activation. Arteriosclerosis, thrombosis, and vascular biology. 2010;30(12):2341-2349.
42. Procter NE, Hurst NL, Nooney VB, et al. New Developments in Platelet Cyclic Nucleotide Signalling: Therapeutic Implications. Cardiovascular drugs and therapy. 2016;30(5):505-513.
43. Smolenski A. Novel roles of cAMP/cGMP‐dependent signaling in platelets. Journal of Thrombosis and Haemostasis. 2012;10(2):167-176.
44. Noé L, Peeters K, Izzi B, Van Geet C, Freson K. Regulators of platelet cAMP levels: clinical and therapeutic implications. Current medicinal chemistry. 2010;17(26):2897-2905.
45. Walter U, Gambaryan S. cGMP and cGMP-dependent protein kinase in platelets and blood cells. cGMP: Generators, Effectors and Therapeutic Implications: Springer; 2009:533-548.
46. Gambaryan S, Kobsar A, Rukoyatkina N, et al. Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of PKA from an NF-κB-IκB complex. Journal of Biological Chemistry. 2010:jbc. M109. 077602.
47. Unsworth A, Kriek N, Bye A, et al. PPAR γ agonists negatively regulate α II bβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity. Journal of Thrombosis and Haemostasis. 2017;15(2):356-369.
48. Brass LF, Zhu L, Stalker TJ. Minding the gaps to promote thrombus growth and stability. The Journal of clinical investigation. 2005;115(12):3385-3392.
49. Brass LF, Zhu L, Stalker TJ. Novel therapeutic targets at the platelet vascular interface. Arteriosclerosis, thrombosis, and vascular biology. 2008;28(3):s43-s50.
50. Falk MM, Baker SM, Gumpert AM, Segretain D, Buckheit RW, 3rd. Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles. Mol Biol Cell. 2009;20(14):3342-3352.
51. Falk MM, Buehler LK, Kumar NM, Gilula NB. Cell-free synthesis and assembly of connexins into functional gap junction membrane channels. Embo j. 1997;16(10):2703-2716.
52. Falk MM, Gilula NB. Connexin membrane protein biosynthesis is influenced by polypeptide positioning within the translocon and signal peptidase access. J Biol Chem. 1998;273(14):7856-7864.
53. Falk MM, Kumar NM, Gilula NB. Membrane insertion of gap junction connexins: polytopic channel forming membrane proteins. J Cell Biol. 1994;127(2):343-355.
54. Thomas T, Jordan K, Simek J, et al. Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci. 2005;118(Pt 19):4451-4462.
55. John SA, Revel J-P. Connexon integrity is maintained by non-covalent bonds: Intramolecular disulfide bonds link the extracellular domains in rat connexin-43. Biochemical and Biophysical Research Communications. 1991;178(3):1312-1318.
56. Crescente M, Pluthero FG, Li L, et al. Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. Arterioscler Thromb Vasc Biol. 2016;36(6):1164-1173.
57. Taylor KA, Wright JR, Vial C, Evans RJ, Mahaut-Smith MP. Amplification of human platelet activation by surface pannexin-1 channels. J Thromb Haemost. 2014;12(6):987-998.
58. Molica F, Stierlin FB, Fontana P, Kwak BR. Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function. Int J Mol Sci. 2017;18(4).
59. Varga-Szabo D, Braun A, Nieswandt B. Calcium signaling in platelets. J Thromb Haemost. 2009;7(7):1057-1066.
60. Jiang L, Bardini M, Keogh A, dos Remedios CG, Burnstock G. P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium. Int J Cardiol. 2005;98(2):291-297.
61. Unsworth AJ, Kriek N, Bye AP, et al. PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity. Journal of thrombosis and haemostasis : JTH. 2017;15(2):356-369.
62. Beck F, Geiger J, Gambaryan S, et al. Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways. Blood. 2014;123(5):e1-e10.
63. Gambaryan S, Kobsar A, Rukoyatkina N, et al. Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J Biol Chem. 2010;285(24):18352-18363.
64. Ma Y, Pitson S, Hercus T, Murphy J, Lopez A, Woodcock J. Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. Journal of Biological Chemistry. 2005;280(28):26011-26017.
65. Kohr MJ, Traynham CJ, Roof SR, Davis JP, Ziolo MT. cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes. J Mol Cell Cardiol. 2010;48(4):645-648.
66. Lampe PD, Lau AF. The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol. 2004;36(7):1171-1186.
67. Liu J, Vitorin JFE, Weintraub ST, et al. Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel function. Journal of Biological Chemistry. 2011:jbc. M111. 218735.
68. Ouyang X, Winbow VM, Patel LS, Burr GS, Mitchell CK, O'Brien J. Protein kinase A mediates regulation of gap junctions containing connexin35 through a complex pathway. Molecular brain research. 2005;135(1):1-11.
69. Pidoux G, Taskén K. Anchored PKA as a gatekeeper for gap junctions. Communicative & Integrative Biology. 2015;8(4):e1057361.
70. van Rijen HV, van Veen TA, Hermans MM, Jongsma HJ. Human connexin40 gap junction channels are modulated by cAMP. Cardiovascular research. 2000;45(4):941-951.
71. Wynn J, Shah U, Murray SA. Redistribution of connexin 43 by cAMP: a mechanism for growth control in adrenal cells. Endocr Res. 2002;28(4):663-668.