An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals

Mekhora, C., Lamport, D. J. ORCID: https://orcid.org/0000-0002-4592-0439 and Spencer, J. P. E. ORCID: https://orcid.org/0000-0003-2931-7274 (2024) An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals. Neurochemistry International, 181. 105900. ISSN 0197-0186 doi: 10.1016/j.neuint.2024.105900

Abstract/Summary

Inflammation has been associated with cognitive decline, whether in the peripheral or central nervous systems. The primary mechanism involves the response of microglia, an immune cell in the brain, which generates proinflammatory mediators such as cytokines, chemokines, and adhesion molecules. The excessive production of pro-inflammatory mediators may accelerate the damage to neurons, contributing to the development of neurodegenerative diseases such as Alzheimer’s disease, mild cognitive impairment, and vascular dementia, as well as a general decline in cognitive function. Various studies have supported the correlation between elevated pro-inflammatory mediators and a decline in cognitive function, particularly in aging and age-related neurodegenerative diseases. Moreover, this association has also been observed in other inflammatory-related conditions, including post-operative cognitive impairment, diabetes, stroke, obesity, and cancer. However, the interaction between inflammatory processes and cognitive function in humans remains unclear and varies according to different health conditions. Therefore, this review aims to consolidate and evaluate the available evidence from original studies as well as meta-analyses in order to provide a greater understanding of the inflammatory process in connection with cognitive function in humans. Furthermore, relevant biological cellular processes, putative inflammatory biomarkers, and the role of nutraceuticals on the interaction between cognitive performance and inflammatory status are outlined.

Item Type	Article
URI	https://centaur.reading.ac.uk/id/eprint/123442
Identification Number/DOI	10.1016/j.neuint.2024.105900
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group Life Sciences > School of Psychology and Clinical Language Sciences > Nutrition and Health
Publisher	Elsevier
Download/View statistics	View download statistics for this item