Vauzour, D. , Houseman, E.J., George, T.W., Corona, G., Garnotel, R., Jackson, K.G., Sellier, C., Gillery, P., Kennedy, O.B., Lovegrove, J.A. and Spencer, J.P.E.
Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers.
British Journal of Nutrition, 103 (8).
To link to this article DOI: 10.1017/S0007114509992959
Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.
|Divisions:||Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group|
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
|Uncontrolled Keywords:||Champagne wine intake, Endothelial-independent vascular function, Matrix metalloproteinase-9 activity, Cardiovascular disease, coronary-heart-disease, rat thoracic aorta, red-wine, dietary polyphenols, matrix metalloproteinases, french paradox, nitric-oxide, white wine, peroxynitrite formation, tissue inhibitors, Adult Aged *Alcohol Drinking Cross-Over Studies Endothelium, Vascular/drug effects/*physiology Female Flavonoids/pharmacology Humans Iontophoresis Laser-Doppler Flowmetry Male Matrix Metalloproteinase 9/blood Middle Aged Oxidants/blood Phenols/pharmacology/urine Single-Blind Method Tissue Inhibitor of Metalloproteinases/blood Vasodilation/drug effects/*physiology *Wine Young Adult |
|Additional Information:||BB/E023185/1/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/F008953/1/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/G005702/1/Biotechnology and Biological Sciences Research Council/United Kingdom
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
|Publisher:||Cambridge University Press|
|BBSRC||Apolipoprotein E genotype and macrophage inflammatory status: Impact of antioxidant/anti-inflammatory dietary components (internal code: H5023200 sponsor code: BB/E023185/1)|
|Enhancement of Learning and Memory by Flavonoids (internal code: H5034200 sponsor code: BB/F008953/1)|
|The Impact of Cocoa Processing on Flavanol Content: Absorption and Health Effects (internal code: H5048400 sponsor code: BB/G005702/1)|
|Date Deposited:||26 Oct 2010 15:55|
|Last Modified:||14 Oct 2013 23:29|
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