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Items where Author is "Greco, Professor Francesca"

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Mitry, M. M.A., Boateng, S. Y., Greco, F. and Osborn, H. M. I. (2023) Bioorthogonal activation of prodrugs, for the potential treatment of breast cancer, using the Staudinger reaction. RSC Medicinal Chemistry, 14 (8). pp. 1537-1548. ISSN 2632-8682 doi: https://doi.org/10.1039/D3MD00137G

Mitry, M. M. A., Greco, F. and Osborn, H. M. I. (2023) In vivo applications of bioorthogonal reactions- chemistry and targeting mechanisms. Chemistry - A European Journal, 29 (20). e202203942. ISSN 0947-6539 doi: https://doi.org/10.1002/chem.202203942

Khater, M., Brazier, J., Greco, F. and Osborn, H. (2023) Anticancer evaluation of new organometallic ruthenium(II) flavone complexes. Medicinal Chemistry, 14 (2). pp. 253-267. ISSN 2632-8682 doi: https://doi.org/10.1039/D2MD00304J

Aljuaid, N., Seitsonen, J., Ruokolainen, J., Greco, F. ORCID: https://orcid.org/0000-0001-7934-0056 and Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 (2022) Micelle and nanotape formation of Benzene Tricarboxamide analogues with selective cancer cell cytotoxicity. ACS Omega, 7 (50). pp. 46843-46848. ISSN 2470-1343 doi: https://doi.org/10.1021/acsomega.2c05940

Khater, M., Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Boateng, S. Y., Greco, F. and Osborn, H. M. I. (2022) Halogenated flavonoid derivatives display antiangiogenic activity. Molecules, 27 (15). 4757. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules27154757

Iflaifel, M., Lim, R. H. ORCID: https://orcid.org/0000-0003-1705-1480, Crowley, C., Greco, F., Ryan, K. and Iedema, R. (2022) Modelling the use of variable rate intravenous insulin infusions in hospitals by comparing Work as Done with Work as Imagined. Research in Social and Administrative Pharmacy, 18 (5). pp. 2786-2795. ISSN 1934-8150 doi: https://doi.org/10.1016/j.sapharm.2021.06.008

Iflaifel, M., Lim, R. ORCID: https://orcid.org/0000-0003-1705-1480, Crowley, C., Greco, F. and Iedema, R. (2022) Using video reflexive ethnography to explore the use of variable rate intravenous insulin infusions. BMC Health Services Research, 22. 545. ISSN 1472-6963 doi: https://doi.org/10.1186/s12913-022-07883-w

Dodd, A., Natfji, A. A. ORCID: https://orcid.org/0000-0002-6168-4632, Evangelinos, A., Grigoletto, A., Pasut, G., Beards, F., Renshall, L., Osborn, H. M. I., Greco, F. and Harris, L. K. (2022) Conjugation to PEG as a strategy to limit the uptake of drugs by the placenta: potential applications for drug administration in pregnancy. Molecular Pharmaceutics, 19 (1). pp. 345-353. ISSN 1543-8392 doi: https://doi.org/10.1021/acs.molpharmaceut.1c00498

Dawood, D. H., Srour, A. M., Saleh, D. O., Huff, K. J., Greco, F. and Osborn, H. M. I. (2021) New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents. RSC Advances, 11. pp. 29441-29452. ISSN 2046-2069 doi: https://doi.org/10.1039/D1RA04758B

Iflaifel, M., Lim, R. ORCID: https://orcid.org/0000-0003-1705-1480, Crowley, C., Ryan, K. and Greco, F. (2021) A detailed analysis of ‘Work As Imagined’ in the use of intravenous insulin infusions in a hospital: a hierarchical task analysis. BMJ Open, 11 (3). e041848. ISSN 2044-6055 doi: https://doi.org/10.1136/bmjopen-2020-041848

Khater, M., Greco, F. and Osborn, H. M. I. (2020) Antiangiogenic activity of flavonoids: a systematic review and meta-analysis. Molecules, 25 (20). 4712. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules25204712

Natfji, A. A. ORCID: https://orcid.org/0000-0002-6168-4632, Nikitin, D. O., Semina, I. I., Moustafine, R. I., Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630, Lin, H., Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238, Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Osborn, H. M. I. and Greco, F. (2020) Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects. Journal of Controlled Release, 322. pp. 227-235. ISSN 0168-3659 doi: https://doi.org/10.1016/j.jconrel.2020.02.037

Salimi, S., Wu, Y., Evangelista Barreiros, M. I., Natfji, A. A. ORCID: https://orcid.org/0000-0002-6168-4632, Khaled, S., Wildman, R., Hart, L. R., Greco, F., Clark, E. A., Roberts, C. J. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2020) A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation. Polymer Chemistry, 11 (20). pp. 3453-3464. ISSN 1759-9954 doi: https://doi.org/10.1039/D0PY00068J

Khater, M., Ravishankar, D., Greco, F. and Osborn, H. (2019) Metal complexes of flavonoids: their synthesis, characterization, and enhanced anti-oxidant and anti-cancer activities. Future Medicinal Chemistry, 11 (21). ISSN 1756-8927 doi: https://doi.org/10.4155/fmc-2019-0237

Castelletto, V., Edwards-Gayle, C. J. C., Greco, F., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Seitsonen, J. and Ruokolainen, J. (2019) Self-assembly, tunable hydrogel properties and selective anti-cancer activity of a carnosine-derived lipidated peptide. Applied Materials & Interfaces, 11 (37). pp. 33573-33580. ISSN 1944-8244 doi: https://doi.org/10.1021/acsami.9b09065

Castelletto, V., Barnes, R. H., Karatzas, K.-A., Edwards-Gayle, C. J. C., Greco, F., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Seitsonen, J. and Ruokolainen, J. (2019) Restructuring of lipid membranes by an arginine-capped peptide bolaamphiphile. Langmuir, 35 (5). pp. 1302-1311. ISSN 0743-7463 doi: https://doi.org/10.1021/acs.langmuir.8b01014

Wahlich, J., Desai, A., Greco, F., Hill, K., Jones, A. T., Mrsny, R. J., Pasut, G., Perrie, Y., Seib, F. P., Seymour, L. W. and Uchegbu, I. F. (2019) Nanomedicines for the delivery of biologics. Pharmaceutics, 11 (5). 210. ISSN 1999-4923 doi: https://doi.org/10.3390/pharmaceutics11050210

Edwards-Gayle, C. J. C., Castelletto, V., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Barrett, G. ORCID: https://orcid.org/0000-0003-1509-0179, Greco, F., Hermida-Merino, D., Rambo, R. P., Seitsonen, J. and Ruokolainen, J. (2019) Self-assembly, antimicrobial activity, and membrane interactions of arginine-capped peptide bola-amphiphiles. ACS Applied Bio Materials, 2 (5). pp. 2208-2218. ISSN 2576-6422 doi: https://doi.org/10.1021/acsabm.9b00172

Gadd, A. J. R., Castelletto, V., Kabova, E., Shankland, K., Perrie, Y., Hamley, I. ORCID: https://orcid.org/0000-0002-4549-0926, Cobb, A. J. A., Greco, F. and Edwards, A. D. ORCID: https://orcid.org/0000-0003-2369-989X (2018) High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation. European Journal of Pharmaceutical Sciences, 123. pp. 268-276. ISSN 0928-0987 doi: https://doi.org/10.1016/j.ejps.2018.07.048

Ravishankar, D., Salamah, M., Akimbaev, A., Williams, H. F., Albadawi, D. A. I., Vaiyapuri, R., Greco, F., Osborn, H. M. I. and Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 (2018) Impact of specific functional groups in flavonoids on the modulation of platelet activation. Scientific Reports, 8. 9528. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-018-27809-z

Edwards-Gayle, C. J. C., Greco, F., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Rambo, R. P., Reza, M., Ruokolainen, J., Skoulas, D. and Iatrou, H. (2018) Self-assembly of telechelic tyrosine end-capped PEO star polymers in aqueous solution. Biomacromolecules, 19 (1). pp. 167-177. ISSN 1525-7797 doi: https://doi.org/10.1021/acs.biomac.7b01420

Castelletto, V., Barnes, R. H., Karatzas, K.-A., Edwards-Gayle, C. J. C., Greco, F., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Rambo, R., Seitsonen, J. and Ruokolainen, J. (2018) Arginine-containing surfactant-like peptides: interaction with lipid membranes and antimicrobial activity. Biomacromolecules, 19 (7). pp. 2782-2794. ISSN 1525-7797 doi: https://doi.org/10.1021/acs.biomac.8b00391

Natfji, A. A., Ravishankar, D., Osborn, H. M. I. and Greco, F. (2017) Parameters affecting the enhanced permeability and retention effect: the need for patient selection. Journal of Pharmaceutical Sciences, 106 (11). pp. 3179-3187. ISSN 0022-3549 doi: https://doi.org/10.1016/j.xphs.2017.06.019

Natfji, A. A., Osborn, H. M. I. and Greco, F. (2017) Feasibility of polymer-drug conjugates for non-cancer applications. Current Opinion in Colloid & Interface Science, 31. pp. 51-66. ISSN 1359-0294 doi: https://doi.org/10.1016/j.cocis.2017.07.004

Wilde, M., Green, R. J., Sanders, M. R. and Greco, F. (2017) Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers. Journal of Drug Targeting, 25 (9-10). pp. 910-918. ISSN 1029-2330 doi: https://doi.org/10.1080/1061186X.2017.1365877

Ravishankar, D., Salamah, M., Attina, A., Pothi, R., Vallance, T. M., Javed, M., Williams, H. F., Alzahrani, E. M. S., Kabova, E., Vaiyapuri, R., Shankland, K., Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352, Strohfeldt, K., Greco, F., Osborn, H. M. I. and Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 (2017) Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Scientific Reports, 7. 5738. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-017-05936-3

Heath, F., Newman, A., Clementi, C., Pasut, G., Lin, H., Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238, Whalley, B. J., Osborn, H. M. I. and Greco, F. (2016) A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion. Polymer Chemistry, 7 (47). pp. 7204-7210. ISSN 1759-9954 doi: https://doi.org/10.1039/c6py01418f

Ravishankar, D., Corona, G., Hogan, S. M., Spencer, J. P. E., Greco, F. and Osborn, H. M. I. (2016) Thioflavones as novel neuroprotective agents. Bioorganic & Medicinal Chemistry, 24 (21). pp. 5513-5520. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2016.09.006

Feula, A., Tang, X., Giannakopoulos, I., Chippindale, A. M., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Greco, F., Buckley, C.P., Siviour, C. R. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2016) An adhesive elastomeric supramolecular polyurethane healable at body temperature. Chemical Science, 7 (7). pp. 4291-4300. ISSN 2041-6539 doi: https://doi.org/10.1039/C5SC04864H

Ravishankar, D., Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Greco, F. and Osborn, H. M. I. (2016) Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity. RSC Advances, 6 (69). pp. 64544-64556. ISSN 2046-2069 doi: https://doi.org/10.1039/C6RA11041J

Baker, B. C., Higgins, C. L., Ravishankar, D., Colquhoun, H. M., Stevens, G. C., Greco, F., Greenland, B. W. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2016) Multifunctional, biocompatible, non-peptidic hydrogels: from water purification to drug delivery. Chemistry Select, 1 (8). pp. 1641-1649. ISSN 2365-6549 doi: https://doi.org/10.1002/slct.201600249

Sartain, F., Greco, F., Hill, K., Rannard, S. and Owen, A. (2016) Emerging nanomedicine applications and manufacturing: progress and challenges. Nanomedicine, 11 (6). pp. 577-580. ISSN 1748-6963 doi: https://doi.org/10.2217/nnm.16.17

Phillips, D. J., Wilde, M., Greco, F. and Gibson, M. I. (2015) Enzymatically-triggered, isothermally responsive polymers: re-programming poly(oligoethylene glycols) to respond to phosphatase. Biomacromolecules, 16 (10). pp. 3256-3264. ISSN 1525-7797 doi: https://doi.org/10.1021/acs.biomac.5b00929

Gadd, A. J. R., Greco, F., Cobb, A. J. A. and Edwards, A. D. ORCID: https://orcid.org/0000-0003-2369-989X (2015) Targeted activation of toll-like receptors: conjugation of a toll-like receptor 7 agonist to a monoclonal antibody maintains antigen binding and specificity. Bioconjugate Chemistry, 26 (8). pp. 1743-1752. ISSN 1043-1802 doi: https://doi.org/10.1021/acs.bioconjchem.5b00302

Ravishankar, D., Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2015.04.056

Rajora, A. K., Ravishankar, D., Osborn, H. M.I. and Greco, F. (2014) Impact of the enhanced permeability and retention (EPR) effect and cathepsins levels on the activity of polymer-drug conjugates. Polymers, 6 (8). pp. 2186-2220. ISSN 2073-4360 doi: https://doi.org/10.3390/polym6082186

Ravishankar, D., Rajora, A., Greco, F. and Osborn, H. (2013) Flavonoids as prospective compounds for anti-cancer therapy. International Journal of Biochemistry and Cell Biology, 45 (12). pp. 2821-2831. ISSN 1878-5875 doi: https://doi.org/10.1016/j.biocel.2013.10.004

Acton, A. L., Fante, C., Flatley, B., Burattini, S., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Wang, Z., Greco, F. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2013) Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules, 14 (2). pp. 564-574. ISSN 1525-7797 doi: https://doi.org/10.1021/bm301881h

Arif, I. S., Hooper, C. L., Greco, F., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Boateng, S. Y. (2013) Increasing doxorubicin activity against breast cancer cells using PPARγ-ligands and by exploiting circadian rhythms. British Journal of Pharmacology, 169 (5). pp. 1178-1188. ISSN 1476-5381 doi: https://doi.org/10.1111/bph.12202

Greco, F., Arif, I., Botting , R., Fante, C., Quintieri, L., Clementi, C., Schiavon, O. and Pasut, G. (2013) Polysialic acid as a drug carrier: evaluation of a new polysialic acid–epirubicin conjugate and its comparison against established drug carriers. Polymer Chemistry, 4. pp. 1600-1609. ISSN 1759-9954 doi: https://doi.org/10.1039/C2PY20876H

Fante, C., Eldar-Boock, A., Satchi-Fainaro, R., Osborn, H. M. I. and Greco, F. (2011) Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent. Journal of Medicinal Chemistry, 54 (14). pp. 5255-5259. ISSN 0022-2623 doi: https://doi.org/10.1021/jm200382r

Blencowe, C. A., Russell, A. T., Greco, F., Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 and Thornthwaite, D. W. (2011) Self-immolative linkers in polymeric delivery systems. Polymer Chemistry, 2 (4). pp. 773-790. ISSN 1759-9954 doi: https://doi.org/10.1039/C0PY00324G

Greco, F. and Vicent, M. (2009) Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. Advanced Drug Delivery Reviews, 61 (13). pp. 1203-1213. ISSN 0169-409X doi: https://doi.org/10.1016/j.addr.2009.05.006

Pasut, G., Greco, F., Mero, A., Mendichi, R., Fante, C., Green, R. J. and Veronese, F. (2009) Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action. Journal of Medicinal Chemistry, 52 (20). pp. 6499-6502. ISSN 0022-2623 doi: https://doi.org/10.1021/jm900804m

Bonjoch, J., Drew, M. G.B., Gonzalez, A., Greco, F., Jawaid, S., Osborn, H. M. I., Williams, N. A.O. and Yaqoob, P. (2008) Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma. Journal of Medicinal Chemistry, 51 (20). pp. 6604-6608. ISSN 0022-2623 doi: https://doi.org/10.1021/jm8007745

Greco, F. and Vicent, M. J. (2008) Polymer-drug conjugates: current status and future trends. Frontiers in Bioscience, 13. pp. 2744-2756. ISSN 1093-9946 doi: https://doi.org/10.2741/2882

Greco, F., Vicent, M.J., Gee, S., Jones, A.T., Gee, J., Nicholson, R.I. and Duncan, R. (2007) Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. Journal of Controlled Release, 117 (1). pp. 28-39. ISSN 0168-3659 doi: https://doi.org/10.1016/j.jconrel.2006.10.012

Bettio, F., Canevari, M., Marzano, C., Bordin, F., Guiotto, A., Greco, F., Duncan, R. and Veronese, F. (2006) Synthesis and biological in vitro evaluation of novel PEG-psoralen conjugates. Biomacromolecules, 7 (12). pp. 3534-3541. ISSN 1525-7797 doi: https://doi.org/10.1021/bm060760n

Vicent, M. J., Greco, F., Nicholson, R. I., Paul, A., Griffiths , P. C. and Duncan, R. (2005) Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. Angewandte Chemie-International Edition, 44 (26). pp. 4061-4066. ISSN 1521-3773 doi: https://doi.org/10.1002/anie.200462960

Greco, F., Vicent, M. J., Penning, N. A., Nicholson, R. I. and Duncan, R. (2005) HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines. Journal of Drug Targeting, 13 (8-9). pp. 459-470. ISSN 1061-186X doi: https://doi.org/10.1080/10611860500383788

Duncan, R., Vicent, M. J., Greco, F. and Nicholson, R. (2005) Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer. Endocrine related cancer, 12. S189-S199. ISSN 1479-6821 doi: https://doi.org/10.1677/erc.1.01045

Book or Report Section

Fante, C. and Greco, F. (2014) Polymer-drug conjugates. In: Bader, R. A. and Putnam, D. A. (eds.) Engineering polymer systems for improved drug delivery. John Wiley & Sons, Hoboken N.J., pp. 59-61. ISBN 9781118098479

Fante, C. and Greco, F. (2013) Polymer-drug conjugates. In: Uchegbu, I. F., Shatzlein, A. G., Cheng, W. P. and Lalatsa, A. (eds.) Fundamentals of Pharmaceutical Nanoscience. Springer, London. ISBN 9781461491637

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